D3900

Desipramine hydrochloride

≥98% (TLC), powder, tricyclic antidepressant

• Formule empirique (notation de Hill): C₁₈H₂₂N₂ · HCl
• Numéro CAS: 58-28-6
• Poids moléculaire : 302.84
• Numéro CE : 200-373-1
• Numéro MDL: MFCD00058108
• Code UNSPSC : 12352116
• ID de substance PubChem : 24278094
• Nomenclature NACRES : NA.77

Propriétés

• product name: Desipramine hydrochloride, ≥98% (TLC), powder
• Pureté: ≥98% (TLC)
• Forme: powder
• Couleur: white to off-white
• Solubilité: H₂O: 50 mg/mL
• Auteur: Sanofi Aventis
• Température de stockage: 2-8°C
• Chaîne SMILES: Cl[H].CNCCCN1c2ccccc2CCc3ccccc13
• InChI: 1S/C18H22N2.ClH/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20;/h2-5,7-10,19H,6,11-14H2,1H3;1H
• Clé InChI: XAEWZDYWZHIUCT-UHFFFAOYSA-N
• Informations sur le gène: human ... SLC6A2(6530)

Description

Description générale

Desipramine, a metabolite of imipramine and iofepramine is an active tricyclic antidepressant.

Application

Desipramine hydrochloride has been used:

• to prevent norepinephrine neuron degeneration and to maximize uptake into DA neurons
• to protect unselective damage to the noradrenergic system
• as a norepinephrine re-uptake inhibitor to treat rats for lesioning

Actions biochimiques/physiologiques

Desipramine is used to treat depression. It is also used to manage enuresis in children. Desipramine helps to eliminate the pain triggered by diabetic neuropathy.

Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (K_i = 4 nM) than the serotonin transporter (K_i = 61 nM).

Caractéristiques et avantages

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Attention

Hygroscopic

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H302,H315,H317,H319,H334,H335
• Conseils de prudence: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves