C1480

Z-Phe-Ala fluoromethyl ketone

≥90% (TLC), powder

• Synonyme(s) : Z-FA-FMK
• Formule linéaire : C₂₁H₂₃N₂O₄F
• Poids moléculaire : 386.42
• Numéro MDL: MFCD00883668
• Code UNSPSC : 12352209
• ID de substance PubChem : 329774889
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Essai: ≥90% (TLC)
• Forme: powder
• Couleur: white to off-white
• Solubilité: DMSO or DMF: 20 mM
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Chaîne SMILES: C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc2ccccc2)C(=O)CF
• InChI: 1S/C21H23FN2O4/c1-15(19(25)13-22)23-20(26)18(12-16-8-4-2-5-9-16)24-21(27)28-14-17-10-6-3-7-11-17/h2-11,15,18H,12-14H2,1H3,(H,23,26)(H,24,27)/t15-,18-/m0/s1
• Clé InChI: ASXVEBPEZMSPHB-YJBOKZPZSA-N

Description

Application

Z-Phe-Ala fluoromethyl ketone (Z-FA-FMK) has been used as a:

• cathepsin inhibitor to study its effects on dendritic cells
• papain-like cysteine protease inhibitor to study its effects on cadmium-induced mitochondrial apoptosis
• cysteine protease inhibitor to study its effects on the interaction of toll-like receptor 9 (TLR9) with granulin in RAW macrophages

Actions biochimiques/physiologiques

Z-Phe-Ala fluoromethyl ketone (Z-FA-FMK) is an inhibitor of cysteine proteases, such as cathepsin B and L. It can also inhibit recombinant effector caspases 2, -3, -6, and -7 and not initiator caspases 8 and -10. Z-FA-FMK plays a role in blocking nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) transactivation. It exhibits therapeutic effects against rheumatoid arthritis.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)