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A9968

Sigma-Aldrich

N-Acetyl-Ile-Glu-Thr-Asp-p-nitroanilide

≥95%

Synonyme(s) :

Ac-IETD-pNA

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About This Item

Formule empirique (notation de Hill):
C27H38N6O12
Poids moléculaire :
638.62
Numéro MDL:
MFCD01318840
Code UNSPSC :
12352209
ID de substance PubChem :
329771065
Nomenclature NACRES :
NA.32

Pureté

≥95%

Forme

powder

Température de stockage

−20°C

Chaîne SMILES 

CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccc(cc1)[N+]([O-])=O

InChI

1S/C27H38N6O12/c1-5-13(2)22(28-15(4)35)26(42)30-18(10-11-20(36)37)24(40)32-23(14(3)34)27(43)31-19(12-21(38)39)25(41)29-16-6-8-17(9-7-16)33(44)45/h6-9,13-14,18-19,22-23,34H,5,10-12H2,1-4H3,(H,28,35)(H,29,41)(H,30,42)(H,31,43)(H,32,40)(H,36,37)(H,38,39)/t13-,14+,18-,19-,22-,23-/m0/s1

Clé InChI

FHURKTIGZAIQGR-BQCLNCLCSA-N

Informations sur le gène

human ... CARD8(22900) , CASP8(841) , CASP8AP2(9994) , CFLAR(8837) , GZMB(3002)
mouse ... CFLAR(117279) , GZMB(171528)
rat ... CASP8(12370) , CFLAR(12633) , GZMB(14939) , RGD1561819(502004) , RGD1562700(502007)

Amino Acid Sequence

NAc-Ile-Glu-Thr-Asp-pNA

Application

Chromogenic substrate for caspase 8 and granzyme B.

Actions biochimiques/physiologiques

IETD is the sequence of amino acid residues 172-175 of procaspase 3, which is cleaved during apoptosis to produce the p12 subunit and a p20 peptide that is further cleaved to form the p17 subunit of mature caspase 3.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Nafiseh Paydarnia et al.
Molecular biology reports, 46(3), 3129-3140 (2019-04-03)
As one of the most prevalent malignancies, breast cancer still remains a significant risk for public health. Common therapeutic strategies include invasive surgery, chemotherapy and anti-herceptin antibodies. Adverse effects, drug resistance and low efficacy of current therapies necessitates the emergence
Yan-Yih Goh et al.
Scientific reports, 6, 36868-36868 (2016-11-15)
Copper complexes with potent anti-tumor effect have been extensively developed. Most investigations of their modes of action focused on the biomolecular targets but not the signal transduction between target binding and cell death. We have previously shown that the cytotoxic
Maria João Valente et al.
Archives of toxicology, 90(8), 1959-1973 (2015-12-18)
Synthetic cathinones have emerged in recreational drug markets as legal alternatives for classical amphetamines. Though currently banned in several countries, 3,4-methylenedioxypyrovalerone (MDPV) is one of the most commonly abused cathinone derivatives worldwide. We have recently reported the potential of MDPV
Xiaosheng Qu et al.
Toxicon : official journal of the International Society on Toxinology, 110, 74-78 (2016-01-01)
The present work investigated the effects of the nematocysts venom (NV) from the Chrysaora helvola Brandt (C. helvola) jellyfish on the human nasopharyngeal carcinoma cell line, CNE-2. The medium lethal concentration (LC50), quantified by MTT assays, was 1.7 ± 0.53 μg/mL (n = 5). An atypical
Huan Yu et al.
Insect science, 27(6), 1158-1172 (2019-12-04)
Apoptosis plays critical roles in multiple biological processes in multicellular organisms. Caspases are known as important participators and regulators of apoptosis. Here, four novel caspase genes of Spodoptera exigua were cloned and characterized, which were designated as SeCasp-1, SeCasp-6, SeCasp-7
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