A9519

N-Acetylmuramyl-L-alanyl-D-isoglutamine hydrate

≥98% (TLC), suitable for ligand binding assays

• Synonyme(s) : Adjuvant Peptide, Muramyl dipeptide
• Formule empirique (notation de Hill): C₁₉H₃₂N₄O₁₁ · xH₂O
• Numéro CAS: 53678-77-6
• Poids moléculaire : 492.48 (anhydrous basis)
• Numéro Beilstein : 4220745
• Numéro CE : 258-696-9
• Numéro MDL: MFCD00077638
• Code UNSPSC : 12352209
• ID de substance PubChem : 24891464
• Nomenclature NACRES : NA.26

Propriétés

• product name: N-Acetylmuramyl-L-alanyl-D-isoglutamine hydrate, ≥98% (TLC)
• Niveau de qualité: 200
• Pureté: ≥98% (TLC)
• Forme: powder
• Technique(s): ligand binding assay: suitable
• Couleur: white
• Application(s): cell analysis
• Température de stockage: −20°C
• Chaîne SMILES: C[C@H](NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O)C(=O)N[C@H](CCC(O)=O)C(N)=O
• InChI: 1S/C19H32N4O11/c1-7(17(30)23-10(16(20)29)4-5-12(26)27)21-18(31)8(2)33-15-13(22-9(3)25)19(32)34-11(6-24)14(15)28/h7-8,10-11,13-15,19,24,28,32H,4-6H2,1-3H3,(H2,20,29)(H,21,31)(H,22,25)(H,23,30)(H,26,27)/t7-,8+,10+,11+,13+,14+,15+,19?/m0/s1
• Clé InChI: BSOQXXWZTUDTEL-QAQREVAFSA-N

Description

Amino Acid Sequence

MurNAc-Ala-Agn

Application

N-Acetylmuramyl-L-alanyl-D-isoglutamine hydrate has been used in staphylococcal cell wall preparation to induce the release of TNF from human monocytes.

Actions biochimiques/physiologiques

Enhances antigenicity of weak antigens, increasing antibody titer.

Muramyl peptides are monomeric components that make up the bacterial cell wall peptidoglycan. It is generally produced by mammalian macrophages, as an immune response in the breakdown of bacterial cell wall. MDP promotes the production of interleukin-1 and tumor necrosis factor (TNF), which increase slow-wave sleep.

N-Acetylmuramyl-L-alanyl-D-isoglutamine (MDP, muramyl dipeptide), a neurotrophic and immunomodulatory factor related to bacterial peptidoglycans, is used as an immune modulation factor that enhances immune response and to study neural development.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)