A6060

Calpain Inhibitor II

powder

• Synonyme(s) : N-Acetyl-L-leucyl-L-leucyl-L-methioninal
• Formule empirique (notation de Hill): C₁₉H₃₅N₃O₄S
• Numéro CAS: 110115-07-6
• Poids moléculaire : 401.56
• Numéro Beilstein : 7693643
• Numéro MDL: MFCD00065506
• Code UNSPSC : 12352200
• ID de substance PubChem : 24891051
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥95% (HPLC)
• Forme: powder
• Couleur: white
• Solubilité: ethanol: 20 mg/mL
• Température de stockage: −20°C
• Chaîne SMILES: [H]C(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O
• InChI: 1S/C19H35N3O4S/c1-12(2)9-16(20-14(5)24)19(26)22-17(10-13(3)4)18(25)21-15(11-23)7-8-27-6/h11-13,15-17H,7-10H2,1-6H3,(H,20,24)(H,21,25)(H,22,26)/t15-,16-,17-/m0/s1
• Clé InChI: RJWLAIMXRBDUMH-ULQDDVLXSA-N

Description

Application

Calpain Inhibitor II has been used in western blotting. It has also been used to study the mechanism of Spy1A (a cyclin-like protein) degradation during cell cycle.

Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons.

Actions biochimiques/physiologiques

Calpain is a cysteine protease expressed in the nervous system. Calpain exhibits a calcium-dependent enzyme activity. In mice models, inhibition of calpain prevents leukocyte infiltration induced by angiotensin II and also attenuates prevascular inflammation.

Autres remarques

Formerly CAS# 136632-32-1

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)