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Key Documents

30290

Sigma-Aldrich

Cytidine 5′-diphosphocholine sodium salt hydrate

≥99.0% (HPLC)

Synonyme(s) :

CDP-choline-Na

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About This Item

Formule empirique (notation de Hill):
C14H25N4NaO11P2 · xH2O
Numéro CAS:
33818-15-4
Poids moléculaire :
510.31 (anhydrous basis)
Numéro Beilstein :
4110040
Numéro MDL:
MFCD00150508
Code UNSPSC :
41106305
ID de substance PubChem :
57648419
Nomenclature NACRES :
NA.51

Source biologique

synthetic

Pureté

≥99.0% (HPLC)

Forme

powder

Impuretés

≤8% water

Température de stockage

2-8°C

Chaîne SMILES 

[Na+].C[N+](C)(C)CCOP([O-])(=O)OP([O-])(=O)OCC1OC([C@H](O)[C@@H]1O)N2C=CC(N)=NC2=O

InChI

1S/C14H26N4O11P2.Na/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21;/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25);/q;+1/p-1/t9?,11-,12-,13?;/m1./s1

Clé InChI

YWAFNFGRBBBSPD-MBWJOHGMSA-M

Application

Cytidine 5′-diphosphocholine (CDP-choline) is generated by choline-phosphate cytidylyltransferase EC 2.7.7.15 in support of the synthesis of phosphatidylcholine. CDP-choline is being used in studies of its affects on neurorecovery.
Cytidine 5′-diphosphocholine sodium salt hydrate has been used as a component of the mixture during the ribonucleotide reductase (RNR) assay in mouse primary pancreatic acinar cells.

Actions biochimiques/physiologiques

Cytidine 5′-diphosphocholine (CDP-choline) is an endogenous compound that plays an important role in the synthesis of phospholipids in the cell membrane. It acts as a choline donor for the biosynthesis of acetylcholine and phosphatidylcholine, a neuronal membrane phospholipid. CDP-choline enhances brain metabolism and influences the levels of various neurotransmitters including dopamine, epinephrine, and acetylcholine. It has been studied as a neuroprotectant after cerebral ischemia. CDP-choline is observed to exhibit therapeutic effects against cognitive impairment arising from multiple causes, cerebral vascular diseases, after-head trauma, and Alzheimer′s disease.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Deniz Bagdas et al.
Behavioural pharmacology, 22(5-6), 589-598 (2011-08-13)
This study was designed to test the effects of intracerebroventricularly (i.c.v.) administered CDP-choline (cytidine-5'-diphosphate-choline; citicoline) and its metabolites in rat models of inflammatory and neuropathic pain. The i.c.v. administration of CDP-choline (0.5, 1.0 and 2.0 µmol) produced a dose and
Tomás Sobrino et al.
Neurological research, 33(6), 572-577 (2011-06-29)
The increase in circulating endothelial progenitor cells (EPCs) is associated with a better outcome in patients with acute ischemic stroke. CDP-choline (citicoline) increases brain plasticity after experimental stroke. Therefore, we study if citicoline treatment could increase the EPC concentration after
Erhan Aslan et al.
Neurological research, 33(7), 766-773 (2011-07-16)
Topical cytidine-5'-diphosphocholine (CDP-choline) has been shown to improve the functional recovery and promote the nerve regeneration of injured sciatic nerves in rats. The aims of this study were to test whether CDP-choline was effective at promoting nerve healing when the
Lorissa J Niebergall et al.
Biochimica et biophysica acta, 1811(12), 1177-1185 (2011-07-13)
Several studies suggest that low levels of hepatic phosphatidylcholine (PC) play a role in the pathogenesis of non-alcoholic steatohepatitis (NASH). CTP: phosphocholine cytidylyltransferase (CT) is the key regulatory enzyme in the CDP-choline pathway for PC biosynthesis. Liver-specific elimination of CTα
Patricia M Arenth et al.
PM & R : the journal of injury, function, and rehabilitation, 3(6 Suppl 1), S123-S131 (2011-07-08)
Cytidine 5'-diphosphocholine (CDP-choline or citicoline) is a highly bioavailable compound with potential benefits for aiding neural repair and increasing acetylcholine levels in the central and peripheral nervous system. As a result, many researchers have investigated the use of CDP-choline for

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