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Coumestrol

Name: Coumestrol
Brand: SIGMA

BioReagent, suitable for fluorescence, ≥97.5% (HPLC)

Synonyme(s) :

7,12-Dihydroxycoumestan

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About This Item

Formule empirique (notation de Hill):

C₁₅H₈O₅

Numéro CAS:

479-13-0

Poids moléculaire :

268.22

Numéro Beilstein :

266702

Numéro CE :

207-525-6

Numéro MDL:

MFCD00016885

Code UNSPSC :

41116107

ID de substance PubChem :

57648278

Nomenclature NACRES :

NA.77

Gamme de produits

BioReagent

Pureté

≥97.5% (HPLC)

Forme

powder

Pf

≥350 °C (lit.)

Solubilité

DMSO: soluble

Fluorescence

λ_ex 377 nm; λ_em 437 nm in 0.1 M Tris pH 8.0

Adéquation

suitable for fluorescence

Chaîne SMILES

Oc1ccc-2c(OC(=O)c3c-2oc4cc(O)ccc34)c1

InChI

1S/C15H8O5/c16-7-1-3-9-11(5-7)19-14-10-4-2-8(17)6-12(10)20-15(18)13(9)14/h1-6,16-17H

Clé InChI

ZZIALNLLNHEQPJ-UHFFFAOYSA-N

Informations sur le gène

human ... ESR1(2099) , ESR2(2100)
mouse ... Esr1(13982)
rat ... Ar(24208)

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Actions biochimiques/physiologiques

Coumestrol has anti-estrogenic actions in the brain and pituitary, mediated through estrogen receptor-α.

Pictogrammes

GHS07

Mention d'avertissement

Warning

Mentions de danger

H302,H315,H319,H335

Conseils de prudence

P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Classification des risques

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

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Phytoestrogen consumption from foods and supplements and epithelial ovarian cancer risk: a population-based case control study.

Elisa V Bandera et al.

BMC women's health, 11, 40-40 (2011-09-29)

While there is extensive literature evaluating the impact of phytoestrogen consumption on breast cancer risk, its role on ovarian cancer has received little attention. We conducted a population-based case-control study to evaluate phytoestrogen intake from foods and supplements and epithelial

Insights into subtle conformational differences in the substrate-binding loop of fungal 17β-hydroxysteroid dehydrogenase: a combined structural and kinetic approach.

Alberto Cassetta et al.

The Biochemical journal, 441(1), 151-160 (2011-09-21)

The 17β-HSD (17β-hydroxysteroid dehydrogenase) from the filamentous fungus Cochliobolus lunatus (17β-HSDcl) is a NADP(H)-dependent enzyme that preferentially catalyses the interconversion of inactive 17-oxo-steroids and their active 17β-hydroxy counterparts. 17β-HSDcl belongs to the SDR (short-chain dehydrogenase/reductase) superfamily. It is currently the

The protective effects of coumestrol against amyloid-β peptide- and lipopolysaccharide-induced toxicity on mice astrocytes.

Man-Hai Liu et al.

Neurological research, 33(6), 663-672 (2011-06-29)

Estrogen replacement therapy can decrease the risk of developing Alzheimer's disease. Phytoestrogens have been proposed as potential alternatives to estrogen replacement therapy. The purpose of this study was to evaluate the in vitro protective effects of coumestrol on mice astrocytes.

Quantification of five isoflavones and coumestrol in various solid agroenvironmental matrices using ¹³c₃-labeled internal standards.

Corinne C Hoerger et al.

Journal of agricultural and food chemistry, 59(3), 847-856 (2011-01-06)

We developed and validated three different sample preparation and extraction methods followed by HPLC-MS/MS (negative electrospray ionization) analysis for the quantification of estrogenic isoflavones (formononetin, daidzein, equol, biochanin A, and genistein) and coumestrol in red clover, soil, and manure. Plant

Mammographic breast density and serum phytoestrogen levels.

Sarah J Lowry et al.

Nutrition and cancer, 64(6), 783-789 (2012-08-07)

Some forms of estrogen are associated with breast cancer risk as well as with mammographic density (MD), a strong marker of breast cancer risk. Whether phytoestrogen intake affects breast density, however, remains unclear. We evaluated the association between serum levels

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