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Key Documents

199R-1

Sigma-Aldrich

CD99 (EPR3097Y) Rabbit Monoclonal Primary Antibody

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100
500

Conjugué

unconjugated

Forme d'anticorps

culture supernatant

Type de produit anticorps

primary antibodies

Clone

EPR3097Y, monoclonal

Description

For In Vitro Diagnostic Use in Select Regions (See Chart)

Forme

buffered aqueous solution

Espèces réactives

human

Conditionnement

vial of 0.1 mL concentrate (199R-14)
vial of 0.5 mL concentrate (199R-15)
bottle of 1.0 mL predilute (199R-17)
vial of 1.0 mL concentrate (199R-16)
bottle of 7.0 mL predilute (199R-18)

Fabricant/nom de marque

Cell Marque™

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

Isotype

IgG

Contrôle

Ewing’s sarcoma

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Visualisation

cytoplasmic, membranous

Informations sur le gène

human ... CD99(4267)

Catégories apparentées

Description générale

CD99, as detected with a variety of antibodies, is expressed by virtually almost all Ewings sarcoma and primitive peripheral neuroectodermal tumors (ES/PNET) and demonstrates strong and diffuse membranous staining. Other tumors that may show CD99 expression include neuroendocrine carcinomas, mesenchymal chondrosarcomas, solitary fibrous tumors, synovial sarcomas, vascular tumors, small round blue cell group of pediatric neoplasms, lymphoblastic lymphoma, acute myeloid leukemia, and myeloid sarcoma. However, strong and diffuse membranous reactivity for CD99 favors ES/PNET over the other diagnostic considerations. The other CD99+ tumors usually show cytoplasmic and more heterogeneous staining. Therefore, when making a final diagnostic interpretation, CD99 must be considered in a panel with other antibodies.

Qualité


IVD
IVD
IVD
RUO

Liaison

CD99 Positive Control Slides, Product No. 199S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Notes préparatoires

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Autres remarques

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informations légales

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Diagnostic Immunohistochemistry: Theranostic and Genomic Applications, 126-126 (2014)
Joseph D Khoury
Advances in anatomic pathology, 12(4), 212-220 (2005-08-13)
The Ewing sarcoma family of tumors (ESFT) comprises morphologically heterogeneous tumors that are characterized by nonrandom chromosomal translocations involving the EWS gene and one of several members of the ETS family of transcription factors. The translocation t(11;22)(q24;q12) is the most
Ewing's sarcoma: new approaches to histogenesis and molecular plasticity.
W J Rettig et al.
Laboratory investigation; a journal of technical methods and pathology, 66(2), 133-137 (1992-02-01)
E J Fellinger et al.
The American journal of surgical pathology, 16(8), 746-755 (1992-08-01)
The HBA71 antigen is an M(r) 30,000/32,000 cell surface glycoprotein (p30/32MIC2), encoded by the pseudoautosomal MIC2 gene on chromosomes X and Y, that is expressed in Ewing's sarcomas. Immunohistochemical studies demonstrate a striking specificity for HBA71 among neoplasms of diverse
I M Ambros et al.
Cancer, 67(7), 1886-1893 (1991-04-01)
This study reports on the specific expression of the MIC2 gene, a pseudoautosomal gene located on the short arms of the X and Y chromosomes, on Ewing's sarcoma (ES) and peripheral primitive neuroectodermal tumor (pPNET) cells. The gene product, a

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