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Y0001262

5-Fluorocytosine

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

5-Fluorocytosine, 4-amino-5-fluoro-2(1H)-pyrimidinone, Flucytosine

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About This Item

Formule empirique (notation de Hill):
C4H4FN3O
Numéro CAS:
2022-85-7
Poids moléculaire :
129.09
Numéro Beilstein :
127285
Numéro MDL:
MFCD00006035
Code UNSPSC :
41116107
ID de substance PubChem :
329831329
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

flucytosine

Fabricant/nom de marque

EDQM

Pf

298-300 °C (dec.) (lit.)

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

NC1=NC(=O)NC=C1F

InChI

1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9)

Clé InChI

XRECTZIEBJDKEO-UHFFFAOYSA-N

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Flucytosine for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Nucleoside analog that has antifungal activities. 5-FC is deaminated by cytosine deaminase to product 5-fluorouracil, resulting in RNA miscoding. 5-Fluorocytosine inhibits DNA and RNA synthesis and interferes with ribosomal protein synthesis.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Pictogrammes

Health hazard
GHS08

Mention d'avertissement

Warning

Mentions de danger

H361

Conseils de prudence

P280

Classification des risques

Repr. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

Désolés, nous n'avons pas de COA pour ce produit disponible en ligne pour le moment.

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Ya-li Yang et al.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 26, 154-161 (2014-07-27)
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Cheshta Sharma et al.
Mycoses, 57(9), 544-552 (2014-04-05)
We investigated the prevalence of vulvovaginal candidiasis due to C. africana in an STD clinic in India and analysed the genetic relatedness of these C. africana isolates with those outside India. A total of 283 germ-tube-positive yeasts were identified by
Sebastian A Mikolajczak et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(9), 1707-1715 (2014-05-16)
Immunization with live-attenuated Plasmodium sporozoites completely protects against malaria infection. Genetic engineering offers a versatile platform to create live-attenuated sporozoite vaccine candidates. We previously generated a genetically attenuated parasite (GAP) by deleting the P52 and P36 genes in the NF54
Hedda Luise Koehling et al.
Journal of clinical microbiology, 53(1), 255-261 (2014-11-14)
Candidemia is an important cause of morbidity and mortality in immunosuppressed patients. Candida isolates must be cultivated, identified, and tested for susceptibility. We compared the performance of a new colorimetric broth microdilution panel (SensiQuattro Candida EU) for antifungal susceptibility testing
Frédéric Gabriel et al.
Antimicrobial agents and chemotherapy, 58(8), 4476-4485 (2014-05-29)
We characterized two additional membrane transporters (Fur4p and Dal4p) of the nucleobase cation symporter 1 (NCS1) family involved in the uptake transport of pyrimidines and related molecules in the opportunistic pathogenic yeast Candida lusitaniae. Simple and multiple null mutants were
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