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Key Documents

M4627

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1-Methylnicotinamide chloride

analytical standard

Synonyme(s) :

N-Methylnicotinic acid amide chloride

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About This Item

Formule linéaire :
C7H9N2OCl
Numéro CAS:
Poids moléculaire :
172.61
Numéro MDL:
Code UNSPSC :
41116107
ID de substance PubChem :
Nomenclature NACRES :
NA.24

Qualité

analytical standard

Niveau de qualité

Pureté

≥97.5%

Forme

powder

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Couleur

white

Application(s)

forensics and toxicology
veterinary
vitamins, nutraceuticals, and natural products

Format

neat

Chaîne SMILES 

[Cl-].C[n+]1cccc(c1)C(N)=O

InChI

1S/C7H8N2O.ClH/c1-9-4-2-3-6(5-9)7(8)10;/h2-5H,1H3,(H-,8,10);1H

Clé InChI

BWVDQVQUNNBTLK-UHFFFAOYSA-N

Description générale

1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT) and exhibits antithrombotic and anti-inflammatory effects.

Application

1-Methylnicotinamide chloride may be used as a standard in the quantification of 1-methylnicotinamide in urine samples using ion pairing reverse-phase high performance liquid chromatography (RP-HPLC).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Actions biochimiques/physiologiques

Urinary excretion product of niacin metabolism

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)


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Consulter la Bibliothèque de documents

Stefan Chłopicki et al.
Pharmacological reports : PR, 64(2), 369-376 (2012-06-05)
Methylnicotinamide (MNA) displays vasoprotective activity, however, the regulation of the activity of nicotinamide-N-methyltransferase (NNMT), is largely unknown. We analyze a possible involvement of IL-6 in the activation of NNMT-MNA pathway during an endurance exercise. FVB, C57Bl/6J IL6(+/+) and C57Bl/6J IL-6(-/-)
Magdalena Sternak et al.
Pharmacological reports : PR, 62(3), 483-493 (2010-07-16)
Nicotinamide N-methyltransferase (NNMT), which converts nicotinamide (NA) to 1-methylnicotinamide (MNA), is up-regulated in the cirrhotic liver. Because MNA displays PGI(2)-dependent anti-inflammatory effects, the up-regulation of NNMT may play a regulatory role in liver inflammation. In the present work, we analyzed
Misha Patel et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 921-922, 87-95 (2013-02-26)
Nicotinamide N-methyltransferase (NNMT, E.C. 2.1.1.1) N-methylates nicotinamide to produce 1-methylnicotinamide. Enhanced NNMT activity is a feature of many types of cancer, and has been linked to processes such as tumour metastasis, resistance to radiotherapy and tumour drug resistance. As such
Tamara Kuchmerovska et al.
Neurochemistry international, 56(2), 221-228 (2009-10-20)
The present study has been designed to establish the potential benefits from 1-methylnicotinamide (MNA) treatment on brain disorders associated with type 1 diabetes. All experiments were carried out after 6 weeks of streptozotocin-induced diabetes (60 mg/kg of body weight, i.p.)
Wu-Ping Sun et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 35(2), 180-185 (2011-09-16)
Nicotinamide and catecholamines are both degraded by S-adenosylmethionine-dependent methylation. Whether excess nicotinamide affects the degradation of catecholamines is unknown. The aim of this study was to investigate the effect of nicotinamide on the methylation status of the body and methylation-mediated

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