579000

Tamoxifen Citrate

Tamoxifen is a potent synthetic anti-estrogenic agent.

• Synonyme(s) : Tamoxifen Citrate, Estrogen Receptor Signaling Regulator I
• Formule empirique (notation de Hill) : C₂₆H₂₉NO · xC₆H₈O₇
• Numéro CAS: 54965-24-1
• Poids moléculaire : 371.51 (salt-free basis)
• Numéro MDL: MFCD00058321
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Description: Merck USA index - 14, 9048
• Niveau de qualité: 100
• Essai: ≥99% (HPLC)
• Forme: powder
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: white to off-white
• Solubilité: ethanol: 5 mg/mL; methanol: 5 mg/mL; water: sparingly soluble
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• Chaîne SMILES: N(CCOc1ccc(cc1)\C(=C(\CC)/c3ccccc3)\c2ccccc2)(C)C.[O-]C(=O)C(O)(CC(=O)[O-])CC(=O)[O-].[H+].[H+].[H+]
• InChI: 1S/C26H29NO.C6H8O7/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,4,19-20H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;
• Clé InChI: FQZYTYWMLGAPFJ-OQKDUQJOSA-N

Description

Description générale

A potent synthetic anti-estrogen. A cell-permeable and reversible inhibitor of protein kinase C (IC₅₀ = 10 µM). Induces apoptosis in human malignant glioma cell lines.

A potent synthetic anti-estrogenic agent. A cell-permeable and reversible inhibitor of protein kinase C (IC₅₀ = 10 µM). Induces apoptosis in human malignant glioma cell lines and inhibits prostate cancer cell growth by induction of p21 protein.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
PKC

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 10 µM against protein kinase C

Avertissement

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Rohlff, C., et al. 1998. Prostate 37, 51.
Couldwell, W.J., et al. 1994. FEBS Lett.345, 43.
Baltuch, G.H., et al. 1993. Neurosurgery33, 495.
Powis, G. 1991. Trends Pharmacol. Sci.12, 188.
Issandou, M., et al. 1990. Cancer Res.50, 5845.
O’Brian, C.A., et al. 1985. Cancer Res.45, 2462.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H302,H350,H360D,H410
• Conseils de prudence: P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313
• Classification des risques: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Repr. 1B
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable