930075

2-fluoro-6-(pyrimidin-5-yl)aniline

≥95%

• Formule empirique (notation de Hill): C₁₀H₈FN₃
• Numéro CAS: 1697040-97-3
• Poids moléculaire : 189.19
• Code UNSPSC : 12352106
• Nomenclature NACRES : NA.06

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95%
• Forme: powder, crystals or chunks
• Couleur: light yellow
• Groupe fonctionnel: fluoro
• Température de stockage: −20°C
• Chaîne SMILES: NC1=C(C2=CN=CN=C2)C=CC=C1F

Description

Application

2-fluoro-6-(pyrimidin-5-yl)aniline is a temporary directing group (TDG) to assist as a co-catalyst for metal catalyzed C-H functionalization. Often in C-H functionalization, an auxiliary compound is used to control site selectivity. These traditionally are covalently bonded to the compound of interest, and must subsequently be removed after functionalization, like a typical protecting group. To simplify the process of C-H functionalization, 2-fluoro-6-(pyrimidin-5-yl)aniline is one of a series of temporary directing groups developed by Deb Maiti′s lab that promote site selectivity without the inclusion of additional synthetic steps.


2-fluoro-6-(pyrimidin-5-yl)aniline is an effective TDG for meta directed C-H functionalization of aldehyde substituted target compounds, with high selectivity.

Autres remarques

1. Imine as a linchpin approach for meta-C–H functionalization2. Transient directing ligands for selective metal-catalysed C–H activation

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable