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677418

Sigma-Aldrich

Hydroxyapatite

nanopowder, <200 nm particle size (BET), ≥97%, synthetic

Synonyme(s) :

Calcium hydroxyphosphate, HAp, Hydroxylapatite

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About This Item

Formule linéaire :
[Ca5(OH)(PO4)3]x
Numéro CAS:
12167-74-7
Poids moléculaire :
502.31
Numéro CE :
235-330-6
Numéro MDL:
MFCD00010904
Code UNSPSC :
12352302
ID de substance PubChem :
24885371
Nomenclature NACRES :
NA.23

Niveau de qualité

100

Pureté

≥97%

Forme

nanopowder
solid

Superficie

>9.4 m2/g

Taille des particules

<200 nm (BET)

Pf

1100 °C (lit.)

Chaîne SMILES 

[Ca++].[Ca++].[Ca++].[Ca++].O[Ca+].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O

InChI

1S/5Ca.3H3O4P.H2O/c;;;;;3*1-5(2,3)4;/h;;;;;3*(H3,1,2,3,4);1H2/q5*+2;;;;/p-10

Clé InChI

XYJRXVWERLGGKC-UHFFFAOYSA-D

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Description générale

Hydroxyapatite(HA) belongs to the family of Ca apatite which resembles natural bone in both structure and chemical composition. It can be prepared by various techniques such as chemical precipitation, hydrothermal, electrospinning, and self-propagating combustion. It is widely used as an implant material for bone regeneration, a drug carrier, and a gene delivery system due to its bioactive and biocompatible nature.

Application

Nanoscale hydroxyapatite particles can be used to prepare bone tissue engineering materials due to their slow biodegradability in situ, good osteoconductive and osteoinductive capabilities.

Poly (sodium 4-styrene sulfonate)-modified hydroxyapatite nanoparticles can be used as a drug carrier for vancomycin. Hydroxyapatite nanoparticles control the release of antibiotics after the implantation of a scaffold in the body.

Porous hydroxyapatite microspheres exhibit a high adsorptive capacity for heavy metals and can be used for the treatment of heavy metal contaminated water.

Caractéristiques et avantages

  • Bioactive and biocompatible
  • Good mechanical strength
  • Porous structure
  • Osteoconductive and osteointegrative properties

Informations légales

Product of Engi-Mat Co.

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
MKCQ2685
MKCN9004
MKCM1889
MKCK9555
MKCK8172

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Consulter la Bibliothèque de documents

Sang-Soo Kim et al.
Biomaterials, 27(8), 1399-1409 (2005-09-20)
Biodegradable polymer/bioceramic composite scaffolds can overcome the limitations of conventional ceramic bone substitutes such as brittleness and difficulty in shaping. However, conventional methods for fabricating polymer/bioceramic composite scaffolds often use organic solvents (e.g., the solvent casting and particulate leaching (SC/PL)
Michiko Sato et al.
Biomaterials, 27(11), 2358-2369 (2005-12-13)
In order to improve orthopedic implant performance, the objective of this in vitro study was to synthesize nanocrystalline hydroxyapatite (HA) powders to coat titanium. HA was synthesized through a wet chemical process. The precipitated powders were either sintered at 1100
Influence of temperature, ripening time and calcination on the morphology and crystallinity of hydroxyapatite nanoparticles.
Pang YX, et al.
J. Eur. Ceram. Soc., 23(10), 1697-1704 (2003)
Hydroxyapatite nanoparticles: a review of preparation methodologies
Ferraz MP, et al.
Journal of Applied Biomaterials & Biomechanics : JABB, 2(2), 74-80 (2004)
Liam M Grover et al.
Biomaterials, 34(28), 6631-6637 (2013-06-12)
Pyrophosphate ions are both inhibitors of HA formation and substrates for phosphatase enzymes. Unlike polyphosphates their hydrolysis results simultaneously in the complete loss of mineral formation inhibition and a localised elevation in orthophosphate ion concentration. Despite recent advances in our
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