Skip to Content
Merck
All Photos(1)

Key Documents

More Documents

P7875

Sigma-Aldrich

Periodic acid

ReagentPlus®, ≥99.0%

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
H5IO6
CAS Number:
10450-60-9
Molecular Weight:
227.94
EC Number:
233-937-0
MDL number:
MFCD00011344
UNSPSC Code:
12352106
PubChem Substance ID:
329820319
NACRES:
NA.21

Quality Level

100

product line

ReagentPlus®

Assay

≥99.0%

form

powder or crystals

reaction suitability

reagent type: oxidant

technique(s)

toxicology assay: suitable

mp

122 °C (lit.)

solubility

water: 100 mg/mL, clear, colorless

SMILES string

OI(O)(O)(O)(O)=O

InChI

1S/H5IO6/c2-1(3,4,5,6)7/h(H5,2,3,4,5,6,7)

InChI key

TWLXDPFBEPBAQB-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Periodic acid, an oxoacid of iodine, is commonly used as a strong oxidizing agent. This inorganic acid is soluble in most solvents including water and ether.

Application

Periodic acid can be used in the following reactions:      
  • Oxidation of alcohols to ketones and aldehydes.
  • Oxidation hydroxylamine derivatives.    
  • Oxidation of arenes to quinones.

It can also be used:     
  • As a stoichiometric oxidant with chromium (IV) acetate for the oxidation of tertiary C−H bonds to tertiary alcohols.     
  • In combination with chromium oxide to oxidize primary alcohols to carboxylic acids; alkylbenzenes to benzoic acids; and cyclic benzyl ethers to the corresponding lactones.      
  • In the selective oxidation of sulfides to sulfoxides using FeCl3 as a catalyst.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Statements

H271,H314,H372,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Ox. Sol. 1 - Skin Corr. 1B - STOT RE 1 Oral

Target Organs

Thyroid

Storage Class Code

5.1A - Strongly oxidizing hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Murad Alturkustani et al.
Journal of neuropathology and experimental neurology, 74(3), 233-240 (2015-02-11)
The pathologic features of adult-onset leukoencephalopathy/leukodystrophy with axonal spheroids (ALAS) are variable, and this has led to different hypotheses as to whether primarily demyelination or axonopathy may underlie this disorder. Typical ALAS pathology is rarely accompanied by focal multiple sclerosis
Zollie A Yavarow et al.
Human molecular genetics, 29(2), 286-294 (2019-12-10)
Glycogen storage disease type Ia (GSD Ia) is caused by autosomal mutations in glucose-6-phosphatase α catalytic subunit (G6PC) and can present with severe hypoglycemia, lactic acidosis and hypertriglyceridemia. In both children and adults with GSD Ia, there is over-accumulation of
H Abdolmohammad-Zadeh et al.
Talanta, 94, 201-208 (2012-05-23)
A simple solid phase extraction system based on the applying the nickel-aluminum layered double hydroxide (Ni-Al LDH) as a nano-sorbent was developed for the speciation analysis of chromium and manganese by flame atomic absorption spectrometry (FAAS). The method is based
Francesca Polverino et al.
The American journal of pathology, 185(3), 741-755 (2014-12-30)
Small animal models of chronic obstructive pulmonary disease (COPD) have several limitations for identifying new therapeutic targets and biomarkers for human COPD. These include a pulmonary anatomy that differs from humans, the limited airway pathologies and lymphoid aggregates that develop
Mohammed Akli Ayoub et al.
PloS one, 10(3), e0119803-e0119803 (2015-03-26)
Understanding functional interactions between G protein-coupled receptors is of great physiological and pathophysiological importance. Heteromerization provides one important potential mechanism for such interaction between different signalling pathways via macromolecular complex formation. Previous studies suggested a functional interplay between angiotensin II
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service