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856525

Sigma-Aldrich

2-Methyl-1,2-di-3-pyridyl-1-propanone

96%

Synonym(s):

Metyrapone, Su-4885

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About This Item

Empirical Formula (Hill Notation):
C14H14N2O
CAS Number:
Molecular Weight:
226.27
Beilstein:
163023
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

96%

form

powder

mp

52-55 °C (lit.)

functional group

ketone

SMILES string

CC(C)(c1cccnc1)C(=O)c2cccnc2

InChI

1S/C14H14N2O/c1-14(2,12-6-4-8-16-10-12)13(17)11-5-3-7-15-9-11/h3-10H,1-2H3

InChI key

FJLBFSROUSIWMA-UHFFFAOYSA-N

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Application

2-Methyl-1,2-di-3-pyridyl-1-propanone inhibits the biosynthesis of corticosterone by blocking the conversion of deoxycorticosterone to corticosterone. It is widely used in adrenocortical-related clinical studies.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Secretion of cortisol and aldosterone as a vulnerable target for adrenal endocrine disruption?screening of 30 selected chemicals in the human H295R cell model.
Uller?s E, et al.
Journal of Applied Toxicology, 28(8), 1045-1053 (2008)
The relationship between adrenocortical function and Hsp70 expression in socially isolated Japanese quail.
Soleimani AF, et al.
Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology, 161(2), 140-144 (2012)
Laia Ribas et al.
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Rijk JCW, et al.
Chemical Research in Toxicology, 25(8), 1720-1731 (2012)
Therese Koal et al.
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