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Merck

1500218

USP

Paroxetine hydrochloride

United States Pharmacopeia (USP) Reference Standard

Sinónimos:

Paroxetine hydrochloride hemihydrate, (3S-trans)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride hemihydrate

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About This Item

Fórmula empírica (notación de Hill):
C19H20FNO3 · HCl · .5 H2O
Número de CAS:
Peso molecular:
374.83
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
NACRES:
NA.24

grado

pharmaceutical primary standard

familia API

paroxetine

fabricante / nombre comercial

USP

aplicaciones

pharmaceutical (small molecule)

formato

neat

cadena SMILES

O.Cl[H].Fc1ccc(cc1)[C@@H]2CCNC[C@H]2COc3ccc4OCOc4c3

InChI

1S/C19H20FNO3.ClH.H2O/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;;/h1-6,9,14,17,21H,7-8,10-12H2;1H;1H2/t14-,17-;;/m0../s1

Clave InChI

QRQSGFFISBKLMZ-YHOFXEKLSA-N

Información sobre el gen

human ... SLC6A4(6532)

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Descripción general

Paroxetine hydrochloride is a phenylpiperidine derivative which is selective serotonin reuptake inhibitor. The protein binding ability is high. It has 2 forms, non-hygroscopic hemihydrate and hygroscopic anhydrate. This drug is seen useful in treating premature ejaculation in men.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Paroxetine hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Acciones bioquímicas o fisiológicas

Paroxetine hydrochloride hemihydrate is one of the most potent and selective of the selective serotonin reuptake inhibitors (SSRI); antidepressant

Nota de análisis

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Otras notas

Sales restrictions may apply.

Producto relacionado

Referencia del producto
Descripción
Precios

Pictogramas

Exclamation markEnvironment

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Sens. 1 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Perinatal outcome following third trimester exposure to paroxetine.
Costei, Adriana Moldovan, et al.
Archives of Pediatrics & Adolescent Medicine, 156.11, 1129-1132 (2002)
C G McMahon et al.
International journal of impotence research, 11(5), 241-245 (1999-12-20)
To evaluate the efficacy of chronic and 'on demand' administration of paroxetine hydrochloride in the drug treatment of premature ejaculation (PE). Ninety-four normally potent men, aged 18-61 y (mean 39 y) with premature ejaculation were treated between January 1996 and
Solid-state forms of paroxetine hydrochloride.
Buxton, P. Christopher, Ian R. Lynch, and John M. Roe.
International Journal of Pharmaceutics, 42.1, 135-143 (1988)
E Di Girolamo et al.
Journal of the American College of Cardiology, 33(5), 1227-1230 (1999-04-08)
The purpose of the study was to determine whether the well tolerated serotonin reuptake inhibitor paroxetine hydrochloride could prevent vasovagal syncope in patients resistant to or intolerant of previous traditional therapies. Serotonergic mechanisms play a major role in the processes
Puja Panwar Hazari et al.
ChemMedChem, 9(2), 337-349 (2014-01-01)
A novel SiX-dipropargyl glycerol scaffold (X: H, F, or (18) F) was developed as a versatile prosthetic group that provides technical advantages for the preparation of dimeric radioligands based on silicon fluoride acceptor pre- or post-labeling with fluorine-18. Rapid conjugation

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