1096724

Carmustine

United States Pharmacopeia (USP) Reference Standard

• Sinónimos: 1,3-Bis(2-chloroethyl)-1-nitrosourea, BCNU
• Fórmula empírica (notación de Hill): C₅H₉Cl₂N₃O₂
• Número de CAS: 154-93-8
• Peso molecular: 214.05
• Número MDL: MFCD00057706
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329749246
• NACRES: NA.24

Propiedades

• grado: pharmaceutical primary standard
• familia API: carmustine
• Formulario: (Oily liquid to amorphous solid)
• fabricante / nombre comercial: USP
• mp: 30 °C (lit.)
• aplicaciones: pharmaceutical (small molecule)
• Formato: neat
• temp. de almacenamiento: −20°C
• cadena SMILES: ClCCNC(=O)N(CCCl)N=O
• InChI: 1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)
• Clave InChI: DLGOEMSEDOSKAD-UHFFFAOYSA-N
• Información sobre el gen: human ... GSR(2936)

Descripción

Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

• Enhancing glioblastoma treatment: Overexpression of Let-7a-3p in U87MG glioblastoma cells enhances chemosensitivity to Carmustine, promoting autophagy and suppressing cell survival, suggesting its role in improving outcomes in glioblastoma multiforme treatment using antineoplastic alkylating compounds (Bahojb Mahdavi et al., 2024).


• Pharmacogenomic profiling in renal cancer: Characterization of mitoribosomal small subunit genes in renal cell carcinoma reveals significant implications for Carmustine′s pharmacogenomic interaction, enhancing understanding of its mechanism in cancer therapy and providing a basis for personalized treatment approaches (Wei et al., 2024).

Nota de análisis

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Otras notas

Sales restrictions may apply.

Información de seguridad

• Pictogramas: GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H300,H350,H360
• Consejos de prudencia: P201 - P280 - P301 + P330 + P331 + P310 - P308 + P313
• Clasificaciones de peligro: Acute Tox. 2 Oral - Carc. 1B - Repr. 1B
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable