U0881

Ácido úrico

BioXtra, ≥99% (HPLC)

• Sinónimos: 2,6,8-Trihidroxipurina
• Fórmula empírica (notación de Hill): C₅H₄N₄O₃
• Número de CAS: 69-93-2
• Peso molecular: 168.11
• Beilstein: 156158
• Número CE: 200-720-7
• Número MDL: MFCD00005712
• Código UNSPSC: 12352005
• ID de la sustancia en PubChem: 24900620
• NACRES: NA.55

Propiedades

• origen biológico: animal (seabird feces (guano))
• Línea del producto: BioXtra
• Ensayo: ≥99% (HPLC)
• Formulario: powder
• impurezas: ≤0.005% Phosphorus (P)
• residuo de ign.: ≤0.1%
• mp: >300 °C (lit.)
• solubilidad: 1 M NaOH: soluble 50 mg/mL, clear, faintly yellow
• trazas de catión: Al: ≤0.005%; Ca: ≤0.01%; Cu: ≤0.0005%; Fe: ≤0.0005%; K: ≤0.05%; Mg: ≤0.001%; NH₄⁺: ≤0.05%; Na: ≤0.1%; Pb: ≤0.001%; Zn: ≤0.0005%
• cadena SMILES: O=C1NC(=O)C2=C(N1)NC(=O)N2
• InChI: 1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)
• Clave InChI: LEHOTFFKMJEONL-UHFFFAOYSA-N

Descripción

Descripción general

Uric acid is the terminal product of purine degradation in humans. It is formed from the action of xanthine oxidase upon xanthine. Elevated levels of uric acid may clinically be manifested as gout. In species other than humans, uric acid can be further metabolized. In mammals other than primates, uric acid is converted to allantoin. In teleost fish, allantoin is further converted to allantoate, which is hydrolyzed to urea and glyoxylate. Uric acid may also be used in the biosynthesis of purines. It has been studied as a scavenger of biological free radicals like peroxynitrite. High-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS) methods for uric acid have been published. Uric acid promotes monocyte chemoattractant protein-1 (MCP-1) expression in vascular smooth muscle cells.

Aplicación

Uric acid has been used:

• to prepare monosodium urate (MSU) crystals to study its effect on nuclear localization leucine-rich-repeat protein 1 (NLRP1) gene expression
• as a reductant to test its protective potential against met-myoglobin formation
• to prepare MSU to study its use as specific ligand of Clec12a.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)