T4425

(6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride

≥98% (HPLC), powder

• Sinónimos: (6R)-BH₄
• Fórmula empírica (notación de Hill): C₉H₁₅N₅O₃ · 2HCl
• Número de CAS: 69056-38-8
• Peso molecular: 314.17
• Número MDL: MFCD00891665
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24277922
• NACRES: NA.77

Propiedades

• product name: (6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride,
• Nivel de calidad: 200
• solubilidad: water, oxygen free: soluble 19.60-20.40 mg/mL, clear to slightly hazy, colorless to faintly yellow
• temp. de almacenamiento: −20°C
• cadena SMILES: Cl.Cl.C[C@H](O)[C@H](O)[C@H]1CNC2=C(N1)C(=O)NC(N)=N2
• InChI: 1S/C9H15N5O3.2ClH/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7;;/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17);2*1H/t3-,4+,6-;;/m0../s1
• Clave InChI: RKSUYBCOVNCALL-NTVURLEBSA-N
• Información sobre el gen: human ... PAH(5053)

Descripción

Descripción general

Tetrahydrobiopterin is a natural cofactor for phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthase and alkylglycerol monooxygenase.

Aplicación

(6R)-BH₄ has been used as a buffer component for assaying tyrosine hydroxylase enzyme activity in mouse brain tissues. (6R)-BH₄ has also been identified as an activator compound from a LOPAC library screen using a fluorogenic α-glucosidase assay.

Acciones bioquímicas o fisiológicas

Lack of tetrahydrobiopterin may cause hyperphenylalaninemia. Diseases like, Parkinson′s, autism, depression and Alzheimer′s shows low concentration of tetrahydrobiopterin in the cerebrospinal fluid. This coenzyme participates in dopamine (DA) synthesis.

Características y beneficios

This compound is featured on the Dopamine, Norepinephrine and Epinephrine Synthesis and Nitric Oxide Synthases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota de preparación

(6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride ((6R)-BH₄ ) is soluble in oxygen free water at 19.60 - 20.40 mg/ml and yields a clear to slightly hazy, colorless to faint yellow solution.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable