Saltar al contenido
Merck
Todas las fotos(3)

Key Documents

View All Documentation

T2573

Sigma-Aldrich

Troglitazone

≥98% (HPLC), powder, PPARγ agonist

Sinónimos:

(±)-5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione, CS-045

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(3)

About This Item

Fórmula empírica (notación de Hill):
C24H27NO5S
Número de CAS:
97322-87-7
Peso molecular:
441.54
Número MDL:
MFCD00878416
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
24724629
NACRES:
NA.77

product name

Troglitazone, ≥98% (HPLC)

Nivel de calidad

200

Análisis

≥98% (HPLC)

formulario

powder

color

white to off-white

solubilidad

DMSO: 20 mg/mL

cadena SMILES

Cc1c(C)c2OC(C)(CCc2c(C)c1O)COc3ccc(CC4SC(=O)NC4=O)cc3

InChI

1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28)

Clave InChI

GXPHKUHSUJUWKP-UHFFFAOYSA-N

Información sobre el gen

human ... PPARA(5465) , PPARG(5468)

Descripción general

Troglitazone is used to treat type 2 diabetes. It is associated with liver injury. Troglitazone functions as an inducer of cytochrome3A.

Aplicación

Troglitazone has been used as a reagent in adipocyte differentiation medium.

Acciones bioquímicas o fisiológicas

PPARγ agonist; anti-diabetic thiazolidinedione (TZD) with anti-inflammatory and anti-tumor activity; induces apoptosis via a p53 pathway.

Características y beneficios

This compound is featured on the Nuclear Receptors (PPARs) and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota de preparación

Studies using troglitazone have reported that it can increase AMP-activated protein kinase (pAMPK) and phosphorylated acetyl-CoA carboxylase in isolated rat extensor digitorum longus muscles1. Furthermore, analysis of troglitazone-mediated autophagy is reported to correlate with the stimulation of AMPK α2.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Los clientes también vieron

Slide 1 of 8

1 of 8

Pleconaril ≥98% (HPLC)

Sigma-Aldrich

SML0307

Pleconaril

Tolcapone ≥98% (HPLC)

Sigma-Aldrich

SML0150

Tolcapone

Sigma-Aldrich

Sigma-Aldrich

SML0896

MCC-555

Hecogenin phyproof® Reference Substance

PHL83508

Hecogenin

T0070907 ≥98% (HPLC)

Sigma-Aldrich

T8703

T0070907

GW0742 ≥98% (HPLC)

Sigma-Aldrich

G3295

GW0742

Zafirlukast ≥98% (HPLC)

Sigma-Aldrich

Z4152

Zafirlukast

Armodafinil ≥98% (HPLC)

Sigma-Aldrich

SML0039

Armodafinil

Troglitazone hepatotoxicity: are we getting closer to understanding idiosyncratic liver injury?
Jaeschke H
Toxicological Sciences, 97(1), 1-3 (2007)
Yuko Okamatsu-Ogura et al.
Scientific reports, 7(1), 6648-6648 (2017-07-29)
We previously reported brown adipocytes can proliferate even after differentiation. To test the involvement of mature adipocyte proliferation in cell number control in fat tissue, we generated transgenic (Tg) mice over-expressing cell-cycle inhibitory protein p27 specifically in adipocytes, using the
Reprogramming of Human Cord Blood CD34+ Cells into Induced MSCs
Hematopoietic Differentiation of Human Pluripotent Stem Cells, 91-101 (2015)
The Practice of Medicinal Chemistry (2015)
Phil June Park et al.
International journal of molecular sciences, 20(8) (2019-04-18)
Adiponectin (APN), released mainly from adipose tissue, is a well-known homeostatic factor for regulating glucose levels, lipid metabolism, and insulin sensitivity. A recent study showed that human hair follicles express APN receptors and the presence of APN-mediated hair growth signaling
Ver todos los artículos relacionados

Artículos

Insulin Signaling and Energy Homeostasis

Glucose metabolism is regulated by the opposing actions of insulin and glucagon. Insulin is released from pancreatic ß cells in response to high blood glucose levels and regulates glucose metabolism through its actions on muscle, liver, and adipose tissue.

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico