T1001
Thyroglobulin from bovine thyroid
powder, ≥90% (agarose gel electrophoresis)
Sinónimos:
Globulins thyro, Thyractin
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About This Item
Productos recomendados
origen biológico
bovine thyroid
Nivel de calidad
Ensayo
≥90% (agarose gel electrophoresis)
Formulario
powder
mol peso
~670 kDa
composición
Iodine, ≥0.20%
análisis de nitrógeno
13.0-16.0% total
ceniza
≤4%
solubilidad
H2O: 20 mg/mL
Nº de acceso UniProt
temp. de almacenamiento
−20°C
Información sobre el gen
cow ... TG(280706)
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Aplicación
Bovine thyroglobulin was shown to stimulate proliferation in rat thyroid follicular cells as well as in primary porcine thyroid epithelial cells. This effect was mediated through PI3K signaling.
Often used as a carrier protein for the production of antibodies. Its advantage is the large number of tyrosine residues that can be used for conjugation using the diazo reaction.
Acciones bioquímicas o fisiológicas
Bovine thyroglobulin is a large, tetrameric glycoprotein produced in the thyroid gland as a precursor to thyroid hormones. Its large size and absence from plasma under normal conditions makes it very immunogenic and reduces the chance that antibodies to this carrier protein will cross-react with plasma proteins in immunoassays. Haptens may be conjugated to thyroglobulin via accessible secondary amines.
Iodine-containing protein that is stored in the thyroid gland. Converted into circulating thyroxines when the thyroid is stimulated by thyroid-stimulating hormone (TSH) from the pituitary. Because its expression is unique to the thyroid, it is a sensitive indicator of recurrence or metastasis of thyroid cancer that has been treated by thyroid ablation.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Artículos
With the emergence of mass spectrometry for the clinical measurement of proteins in biological matrices, the development of biological reference materials will continue to grow in importance.
Separation of null
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