SRP8050

Profilin from Toxoplasma gondii

recombinant, expressed in E. coli, >95% (SDS-PAGE)

• Sinónimos: Inflammatory profilin, T Cell Membrane Protein 1
• Código UNSPSC: 12352202
• NACRES: NA.32

Propiedades

• origen biológico: Toxoplasma gondii
• recombinante: expressed in E. coli
• Análisis: >95% (SDS-PAGE)
• formulario: lyophilized
• mol peso: ~20 kDa by SDS-PAGE
• envase: pkg of 10 μg
• condiciones de almacenamiento: avoid repeated freeze/thaw cycles
• impurezas: <0.01 EU/μg endotoxin, tested
• color: white
• Nº de acceso UniProt: Q58NA1
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• Información sobre el gen: Toxoplasma gondii ... PRF(7900190)

Descripción

Acciones bioquímicas o fisiológicas

Profilin is a protozoan parasite protein. It activates toll-like receptor 11 (TLR11), which is an intracellular receptor localized on the endoplasmic reticulum (ER). TLR11 acts as an innate immune sensor for T. gondii profilin (TgPRF).The 12 membrane-spanning ER-resident protein UNC93B1 directly binds TLR11 and control the activation of dendritic cells in response to profilin (Toxoplasma gondii) and parasitic infection in vivo. TLR12 also has an ability to interact with (TgPRF). TLR12 is adequate for recognizing profilin in plasmacytoid dendritic cells (pDCs), whereas TLR11 and TLR12 are both needed in macrophages and conventional DCs. In contrast to TLR11, TLR12-deficient mice fail to resist T. gondii infection.

Forma física

Lyophilized from PBS.

Reconstitución

Reconstitute with 100 μL deionized water.

Otras notas

Recombinant profilin (Toxoplasma gondii) (aa 1-163).

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable