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Merck
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Key Documents

SRP6539

Sigma-Aldrich

NQO1 human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Sinónimos:

Azoreductase, DT-Diaphorase (DTD), Dioxin-inducible 1, Disphorase-4 (DIA4), Menadione Reductase, NAD(P)H Dehydrogenase (Quinine) 1 (NQO1), NAD(P)H Quinone Oxireductase, Phylloquinone Reductase, Quinone Oxidoreductase 1, Quinone Reductase 1 (QR1)

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About This Item

Código UNSPSC:
12352200
NACRES:
NA.77

origen biológico

human

recombinante

expressed in E. coli

Análisis

≥90% (SDS-PAGE)

formulario

liquid

mol peso

~30 kDa (Human NQO1 aa 1-274 is fused at the C-terminus to a His-tag.)

envase

pkg of 10 and 50 μg

impurezas

<0.1 EU/μg endotoxin (LAL test)

Nº de acceso UniProt

P15559

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

Información sobre el gen

human ... NQO1(1728)

Descripción general

Research area: Cell signaling. NQO1 (NAD(P)H quinone dehydrogenase 1) is an obligate two-electron reductase. It is a cytoplasmic, homodimeric protein, with one FAD molecule per monomer. This gene is localized to human chromosome 16q23. It shows a wide range of tissue expression.

Acciones bioquímicas o fisiológicas

NQO1 (NAD(P)H quinone dehydrogenase 1) uses NADH or NADPH as a reducing cofactor, and is characterized by its inhibition by dicoumarol. It is thought to confer protection against natural and exogenous quinones. It is involved in the conversion of benzene derived quinones to less toxic hydroquinones, and participates in benzene-associated hematotoxicity. It is involved in the reduction and eventual activation of few chemotherapeutic drugs and of environmental carcinogens, such as heterocyclic amines, nitroaromatic compounds, and possibly cigarette smoke particulate. C609T null variant of this gene is linked with breast cancer susceptibility in north Indian patients. NQO1 is up-regulated in serous ovarian carcinoma, and this expression is linked with poor prognosis; hence, this gene has potential as biomarker for the same.

Forma física

0.2 μm-filtered solution in 50 mM Tris-Cl, pH 8.0, containing 1 mM DTT.

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H319

Clasificaciones de peligro

Eye Irrit. 2

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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The C609T (Pro187Ser) Null Polymorphism of the NQO1 Gene Contributes Significantly to Breast Cancer Susceptibility in North Indian Populations: a Case Control Study.
Yadav P, et al.
Asian Pacific Journal of Cancer Prevention, 17(3), 1215-1219 (2016)
NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector.
Dinkova-Kostova AT and Talalay P.
Archives of Biochemistry and Biophysics, 501(1), 116-123 (2010)
Prevalence of the inactivating 609C-->T polymorphism in the NAD(P)H:quinone oxidoreductase (NQO1) gene in patients with primary and therapy-related myeloid leukemia.
Larson RA, et al.
Blood, 94(2), 803-807 (1999)
High expression of NQO1 is associated with poor prognosis in serous ovarian carcinoma.
Cui X, et al.
BMC Cancer, 15:244 (2015)
Xiang Li et al.
Bioorganic & medicinal chemistry, 24(5), 1006-1013 (2016-01-25)
A new series of ortho-naphthoquinone analogs of β-lapachone were designed, synthesized and evaluated. The biological results indicated that most of our compounds were efficient substrates for NQO1. The new scaffold with water-soluble side chain resulted in greater solubility under acidic
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