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Merck
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Key Documents

SRP6455

Sigma-Aldrich

EpCAM/CD326 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Sinónimos:

DIAR5, EGP2, EGP314, EGP40, ESA, GA733-2, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK1, TACSTD1, TROP1

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About This Item

Código UNSPSC:
12352200
NACRES:
NA.32

origen biológico

human

recombinante

expressed in HEK 293 cells

etiqueta

6-His tagged (C-terminus)

Análisis

≥95% (SDS-PAGE)

formulario

lyophilized

mol peso

calculated mol wt 29 kDa (after removal of signal peptide.)
observed mol wt 33-36 kDa by SDS-PAGE

envase

pkg of 10 and 50 μg

impurezas

<1 EU/μg endotoxin (LAL test)

Nº de acceso UniProt

P16422

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

Información sobre el gen

human ... EPCAM(4072)

Descripción general

DTT-reduced. rh EpCAMProtein migrates as poly peptide due to glycosylation. Gln24 is the predicted N-terminal.
Epithelial cell adhesion molecule (EpCAM) is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A (mAb) antigen. The gene encoding EpCAM is localized on human chromosome 2p21.

Acciones bioquímicas o fisiológicas

Epithelial cell adhesion molecule (EpCAM) is intricately linked with the cadherin-catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The protein has several cellular functions, like epithelial-specific cell-adhesion, cell signaling, migration, proliferation and differentiation. It is expressed in most epithelial malignancies (like epithelial ovarian cancer) and was reported as a tumor marker or a candidate of molecular targeting therapy. EpCAM cross signaling with N-cadherin involves phosphoinositide-3-kinase (Pi3K), resulting in the abrogation of the cadherin adhesion complexes in epithelial cells.

Forma física

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

Reconstitución

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Overexpression of epithelial cell adhesion molecule (Ep-CAM) is an independent prognostic marker for reduced survival of patients with epithelial ovarian cancer.
Spizzo G
Gynecologic Oncology, 103(2), 483-488 (2006)
Cadherins are regulated by Ep-CAM via phosphaditylinositol-3 kinase.
Winter MJ
Molecular and Cellular Biochemistry, 302(1-2), 19-26 (2007)
Epithelial cell adhesion molecule expression (CD326) in cancer: a short review.
Patriarca C
Cancer Treatment Reviews, 38(1), 68-75 (2012)
The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies
Ke Yang
Laboratory Investigation; a Journal of Technical Methods and Pathology, 96, 116-136 (2016)
The Epithelial Cell Adhesion Molecule (Ep-CAM) as a Morphoregulatory Molecule Is a Tool in Surgical Pathology
Manon J. Winter
The American Journal of Pathology, 163(6), 2139-2148 (2003)
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