SRP6003

Procalcitonin human

recombinant, expressed in E. coli, ≥97% (SDS-PAGE), ≥97% (HPLC)

• Sinónimos: CALC1, CALCA, CGRP, Calcitonin
• Número de CAS: 1476823-80-9
• Código UNSPSC: 51111800
• NACRES: NA.32

Propiedades

• origen biológico: human
• recombinante: expressed in E. coli
• Análisis: ≥97% (HPLC); ≥97% (SDS-PAGE)
• formulario: lyophilized
• potencia: 80 ng/mL
• mol peso: 12.796 kDa
• envase: pkg of 10 μg
• técnicas: cell culture | mammalian: suitable
• impurezas: Endotoxin, tested
• Nº de acceso NCBI: P01258
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... N/A(796)

Descripción

Descripción general

The gene CALC1 (calcitonin 1) is mapped to human chromosome 11. CALC1 encodes for preprocalcitonin. Preprocalcitonin is cleaved by endopeptidase at the amino-terminal to produce procalcitonin. Procalcitonin works as a peptide hormone and is mainly produced by the C cells of the thyroid and certain endocrine cells of the lung. Under normal expression conditions, procalcitonin is immediately cleaved into three specific fragments, an N terminal residue, calcitonin and katacalcin. Recombinant human procalcitonin produced in Escherichia coli is a single, non-glycosylated, polypeptide chain containing 116 amino acids with a molecular weight of 12,796 Daltons.

Aplicación

Procalcitonin human has been used in in vitro vascular permeability assay.

Acciones bioquímicas o fisiológicas

Procalcitonin is a prohormone of calcitonin. Levels of unprocessed procalcitonin rise significantly after bacterial infection, trauma or shock. Procalcitonin is also associated with systemic complications in humans suffering from acute pancreatitis.

Forma física

Lyophilized from a 10 mM sodium phosphate buffer, pH 7.5.

Reconstitución

Centrifuge the vial prior to opening. Reconstitute in sterile H?O to a concentration of 0.1 mg/ml.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable