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Merck
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Key Documents

SRP4623P

Sigma-Aldrich

Myostatin Proform human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Sinónimos:

GDF-8, Growth Differentiation Factor 8, MSTN, MSTN Muscle Hypertrophy

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About This Item

Número MDL:
MFCD03457656
Código UNSPSC:
12352200
NACRES:
NA.32

origen biológico

human

recombinante

expressed in E. coli

Análisis

≥98% (HPLC)
≥98% (SDS-PAGE)

formulario

lyophilized

mol peso

~27.8 kDa

envase

pkg of 10 μg

impurezas

endotoxin, tested

Nº de acceso NCBI

O14793

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

Información sobre el gen

human ... MSTN(2660)

Descripción general

MSTN (myostatin) belongs to the transforming growth factor-β (TGF β) superfamily containing numerable homologous cytokine proteins. This gene is expressed in skeletal muscle, and codes for a precursor protein composed of an N-terminal leader peptide, a pro-peptide domain, and a C-terminal domain. This precursor protein is proteolytically cleaved by bone morphogenetic protein 1 (BMP-1) at a conserved four amino acid RSRR site to produce the 13kDa mature protein.

Acciones bioquímicas o fisiológicas

MSTN (myostatin) functions as a negative modulator of muscle cell development. It functions through forming heteromeric receptor complexes such as with activin type II receptor B (ActRIIB), and with lesser affinity with ActIIA. This interaction results in the recruitment of type I receptors like activin receptor-like kinase 4 (ALK4) or ALK5, leading to the phosphorylation of Smad2 (small mothers against decapentaplegic) and Smad3, which move to the nucleus and suppress myogenesis. In MSTN-null mice, there is delayed skin wound healing due to the increased expression of decorin, an endogenous transforming growth factor-β (TGF β) suppressor. Topical treatment with TGF-β1 restored skin wound healing, suggesting that MSTN agonists might have therapeutic beneficial in skin wound repair.

Forma física

Lyophilized without any additives.

Reconstitución

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1 to 1.0 mg/mL. This solution can then be diluted into other aqueous buffers.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Myostatin-null mice exhibit delayed skin wound healing through the blockade of transforming growth factor-? signaling by decorin.
Zhang C
American Journal of Physiology. Cell Physiology, 302, 1213-1225 (2012)
Myostatin rapid sequence evolution in ruminants predates domestication.
Tellgren A
Molecular Phylogenetics and Evolution, 33, 782-790 (2004)
Qiqi Yang et al.
Disease models & mechanisms, 12(2) (2019-02-06)
Cancer cachexia affects up to 80% of patients with advanced solid cancer and leads to excessive muscle wasting. Here, using an inducible zebrafish hepatocellular carcinoma (HCC) model driven by oncogenic krasG12V , we observed a progressive muscle-wasting phenotype in adult

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