SML1664

Deoxynivalenol Ready Made Solution

1 mg/mL

• Sinónimos: (3α,7α)-3,7,15-trihydroxy-12,13-epoxytrichothec-9-en-8-one, 4-Deoxynivalenol, DON, Dehydronivalenol, RD-toxon, Vomitoxin
• Fórmula empírica (notación de Hill): C₁₅H₂₀O₆
• Número de CAS: 51481-10-8
• Peso molecular: 296.32
• Código UNSPSC: 12352200

Propiedades

• origen biológico: Fusarium sp. (Fusarium asiaticum)
• Nivel de calidad: 200
• formulario: solution (ethanol: 2-propanol 95:5)
• condiciones de almacenamiento: protect from light
• concentración: 1 mg/mL
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• InChI: 1S/C15H20O6/c1-7-3-9-14(5-16,11(19)10(7)18)13(2)4-8(17)12(21-9)15(13)6-20-15/h3,8-9,11-12,16-17,19H,4-6H2,1-2H3/t8-,9-,11-,12-,13-,14-,15+/m1/s1
• Clave InChI: LINOMUASTDIRTM-QGRHZQQGSA-N

Descripción

Acciones bioquímicas o fisiológicas

Deoxynivalenol (DON) is a trichothecene mycotoxin that inhibits the synthesis of DNA and RNA as well as protein synthesis at the ribosomal level. DON induces IL-6 mediated serum hyperelevation of IgA, as well as phosphorylation of extracellular signal regulated protein kinases 1 and 2 (ERK 1,2) and c-Jun N-terminal kinases 1 and 2 (JNK 1,2) in mice. An in vitro study with porcine ovarian granulosa cells suggests a dose dependent association of DON on porcine ovarian functions. It was also shown that LPS and its downstream mediators can interact with DON to modulate proliferative, cytotoxic and apoptotic outcomes in leukocytes in a tissue specific manner.

Nota de preparación

Deoxynivalenol ready-made solution (1 mg/ml in Ethanol: 2-propanol 95:5) can be diluted in aqueous buffers to a working concentration of 0.1-1 μg/ml (1:1000).

Información de seguridad

• Pictogramas: GHS02,GHS07
• Palabra de señalización: Danger
• Frases de peligro: H225 - H319
• Consejos de prudencia: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - Flam. Liq. 2
• Código de clase de almacenamiento: 3 - Flammable liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): 57.2 °F
• Punto de inflamabilidad (°C): 14 °C