SML1297

SB269652

≥98% (HPLC)

• Sinónimos: N-[trans-4-[2-(7-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-1H-indole-2-carboxamide
• Fórmula empírica (notación de Hill): C₂₇H₃₀N₄O
• Número de CAS: 215802-15-6
• Peso molecular: 426.55
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Análisis: ≥98% (HPLC)
• formulario: powder
• color: white to beige
• solubilidad: DMSO: 2 mg/mL
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C27H30N4O/c28-17-20-5-8-21-12-14-31(18-23(21)15-20)13-11-19-6-9-24(10-7-19)29-27(32)26-16-22-3-1-2-4-25(22)30-26/h1-5,8,15-16,19,24,30H,6-7,9-14,18H2,(H,29,32)/t19-,24-
• Clave InChI: JGLGOAQPUQITLD-OGAOHHHESA-N

Descripción

Acciones bioquímicas o fisiológicas

SB269652 is an allosteric modulator of D2 dopamine receptors. SB269652 binds to an allosteric site that is distinct from the orthosteric bound by typical D2 antagonists and is only revealed in D2 receptor dimers. SB269652 is bitopic, binding to an orthosteric site one one partner in the dimer and the allosteric site in the other. Engagement of this secondary pocket at the extracellular end of TM2 and TM7 is a new mechanism of modulating binding of a ligand to the orthosteric site of a second protomer by a G-protein coupled receptor.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable