SML1277

Geldanamycin-FITC

≥98% (HPLC), from Streptomyces hygroscopicus

• Sinónimos: Geldanamycin, fluorescein isothiocyanate labeled
• Fórmula empírica (notación de Hill): C₅₅H₆₃N₅O₁₃S
• Peso molecular: 1034.18
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• origen biológico: Streptomyces hygroscopicus
• Nivel de calidad: 200
• Análisis: ≥98% (HPLC)
• formulario: powder
• condiciones de almacenamiento: protect from light
• color: yellow to yellow-orange
• solubilidad: DMSO: soluble 5 mg/mL
• espectro de actividad antibiótica: neoplastics
• Modo de acción: enzyme | inhibits
• temp. de almacenamiento: −20°C

Descripción

Descripción general

Chemical structure: benzenoid

Acciones bioquímicas o fisiológicas

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.

Geldanamycin-FITC is a fluorescent derivative of geldanamycin. It is used as a fluorescent tracer for heat shock protein 90 (HSP90) inhibitors in fluorescence polarization (FP) competition binding assay.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable