SML0693

LY-333531 hydrochloride

≥98% (HPLC)

• Sinónimos: (9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-Dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione hydrochloride, Ruboxistaurin
• Fórmula empírica (notación de Hill): C₂₈H₂₈N₄O₃ · HCl
• Número de CAS: 169939-93-9
• Peso molecular: 505.01
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• condiciones de almacenamiento: desiccated; protect from light
• color: orange-red
• solubilidad: DMSO: 10 mg/mL, clear
• temp. de almacenamiento: −20°C
• cadena SMILES: Cl.[n]21c3c(c(c2)C4=C(c5c6c([n](c5)CC[C@H](OCC1)CN(C)C)cccc6)C(=O)NC4=O)cccc3
• InChI: 1S/C28H28N4O3.ClH/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24;/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34);1H/t18-;/m0./s1
• Clave InChI: NYQIEYDJYFVLPO-FERBBOLQSA-N

Descripción

Descripción general

LY-333531 hydrochloride is also known as ruboxistaurin.

Aplicación

LY-333531 hydrochloride/ruboxistaurin has been used as a PKCB blocker to compare phosphopeptides derived from stimulated wild-type cells to phosphopeptides derived from either PKCB knockout cells or wild-type cells.

Acciones bioquímicas o fisiológicas

LY333531 is a potent inhibitor of protein kinase Cβ (PKCβ; 4.7 and 5.9 nM IC₅₀ values for PKCβ1 and PKCβ2, respectively). PKCβ isoforms are overexpressed in states of oxidative stress, especially in association with diabetes. In diabetic rats, LY333531 improves blood flow and leukocyte entrapment in the retina, and protects against myocardial hypertrophy and cardiac dysfunction.

LY333531 is a potent, specific inhibitor of PKCβ.

Características y beneficios

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Otras notas

Light sensitive

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable