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Merck
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Key Documents

SML0602

Sigma-Aldrich

Propiverine hydrochloride

≥98% (HPLC)

Sinónimos:

α,α-Diphenyl-α-propoxyacetic acid hydrochloride 1-methyl-4-piperidyl ester, α-Phenyl-α-propoxybenzeneacetic acid 1-methyl-4-piperidinyl ester hydrochloride, (1-Methylpiperidin-1-ium-4-yl) 2,2-diphenyl-2-propoxyacetate chloride, 1-Methyl-4-piperidyl diphenylpropoxyacetate hydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C23H29NO3 · HCl
Número de CAS:
54556-98-8
Peso molecular:
403.94
Código UNSPSC:
12352200
NACRES:
NA.77

Nivel de calidad

100

Análisis

≥98% (HPLC)

formulario

powder

condiciones de almacenamiento

desiccated

color

white to beige

solubilidad

H2O: 5 mg/mL, clear (warmed)

temp. de almacenamiento

2-8°C

InChI

1S/C23H29NO3.ClH/c1-3-18-26-23(19-10-6-4-7-11-19,20-12-8-5-9-13-20)22(25)27-21-14-16-24(2)17-15-21;/h4-13,21H,3,14-18H2,1-2H3;1H

Clave InChI

KFUJMHHNLGCTIJ-UHFFFAOYSA-N

Descripción general

Propiverine hydrochloride drug is a tertiary amine with spasmolytic and analgesic properties. This drug exerts neurotropic and musculotropic effects on the urinary bladder and smooth muscles. Propiverine hydrochloride has a half-life of 20 hours.

Acciones bioquímicas o fisiológicas

Propiverine is an antimuscarinic drug used for the treatment of overactive blaqdder and urinary incontinence. Propiverine and/or its metabolites also have calcium channel blocking properties in addition to antimuscarinic activity, which may contribute to the clinical activity.

Características y beneficios

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogramas

CorrosionExclamation mark
GHS05,GHS07

Palabra de señalización

Danger

Frases de peligro

H315 - H318 - H335

Clasificaciones de peligro

Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Tetsuo Ogata et al.
Chemical & pharmaceutical bulletin, 60(8), 976-984 (2012-08-07)
The aim of the present study was to mask the bitterness of propiverine hydrochloride (P-4) by converting it to propiverine free base. Fine granules comprising the free base, which was converted from P-4 by desalination, were prepared. By using Fourier
Editorial comment from Dr Sekido to propiverine hydrochloride in Japanese patients with overactive bladder: a randomized, double-blind, placebo-controlled trial.
Noritoshi Sekido
International journal of urology : official journal of the Japanese Urological Association, 18(5), 373-374 (2011-03-09)
Yasue Kubota et al.
Neurourology and urodynamics, 30(7), 1309-1314 (2011-05-12)
To evaluate the relationship between treatment-related changes in Overactive Bladder Symptom Scores (OABSS) and health-related quality of life (HRQOL) questionnaires. Ninety-five patients with OAB symptoms were enrolled. All patients completed the OABSS, International Prostate Symptom Score (IPSS)-Quality Of Life (QOL)
Editorial comment from Dr Dmochowski to propiverine hydrochloride in Japanese patients with overactive bladder: a randomized, double-blind, placebo-controlled trial.
Roger R Dmochowski
International journal of urology : official journal of the Japanese Urological Association, 18(5), 374-374 (2011-03-02)
Daniela Schultz-Lampel et al.
Deutsches Arzteblatt international, 108(37), 613-620 (2011-10-07)
Urinary incontinence (bedwetting, enuresis) is the commonest urinary symptom in children and adolescents and can lead to major distress for the affected children and their parents. Physiological and non-physiological types of urinary incontinence are sometimes hard to tell apart in
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Acetylcholine Receptors (Muscarinic)

Muscarinic acetylcholine receptors are G protein-coupled receptors (GPCRs) and mediate acetylcholine actions in the CNS and non-nervous tissues. Learn more about acetylcholine receptors and their role in cell signaling.

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