SML0569

RO-3306

≥98% (HPLC), powder, CDK1 inhibitor

• Sinónimos: (5Z)-5-Quinolin-6-ylmethylene-2-[(thiophen-2-ylmethyl)-amino]-thiazol-4-one, 5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone
• Fórmula empírica (notación de Hill): C₁₈H₁₃N₃OS₂
• Número de CAS: 872573-93-8
• Peso molecular: 351.45
• Número MDL: MFCD17392573
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825559
• NACRES: NA.77

Propiedades

• product name: RO-3306, ≥98% (HPLC)
• Análisis: ≥98% (HPLC)
• formulario: powder
• color: off-white to brown
• solubilidad: DMSO: 5 mg/mL, clear
• temp. de almacenamiento: 2-8°C
• cadena SMILES: O=C1N=C(NCC2=CC=CS2)S/C1=C\C3=CC4=C(C=C3)N=CC=C4
• InChI: 1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)/b16-10-
• Clave InChI: XOLMRFUGOINFDQ-YBEGLDIGSA-N

Descripción

Aplicación

RO-3306 has been used:

• To study the significance of CA4-mediated cytotoxicity in mitotic arrest
• In cell cycle synchronization to conduct a study on proteomics
• As a CDK1 inhibitor, to prevent early mitotic entry

Acciones bioquímicas o fisiológicas

CDK1 (cyclin dependent kinase 1) is considered to be the “master switch” in cell division, which maintains the mitotic state of cells.

RO-3306 is a selective ATP-competitive inhibitor of CDK1. It inhibites CDK1 cyclin B1 activity with Ki of 35 nM, nearly 10-fold selectivity relative to CDK2/cyclin E and over 50-fold relative to CDK4/cyclin D. RO-3306 has been used to cause cell cycle arrest at the G2/M boundary.

Características y beneficios

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable