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SML0488

Sigma-Aldrich

Dobesilate Calcium

≥98% (HPLC)

Sinónimos:

2,5-Dihydroxybenzenesulfonic acid calcium salt, 205E, Calcium 2,5-dihydroxybenzenesulfonate, Calcium Dobesilate, Hydroquinone calcium sulfonate

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About This Item

Fórmula empírica (notación de Hill):
C6H5O5S · 0.5Ca
Número de CAS:
20123-80-2
Peso molecular:
209.20
Número MDL:
MFCD00867249
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329825438
NACRES:
NA.77

Nivel de calidad

100

Ensayo

≥98% (HPLC)

Formulario

powder

color

white to beige

solubilidad

H2O: 15 mg/mL, clear

temp. de almacenamiento

room temp

cadena SMILES

[Ca++].Oc1ccc(O)c(c1)S([O-])(=O)=O.Oc2ccc(O)c(c2)S([O-])(=O)=O

InChI

1S/2C6H6O5S.Ca/c2*7-4-1-2-5(8)6(3-4)12(9,10)11;/h2*1-3,7-8H,(H,9,10,11);/q;;+2/p-2

Clave InChI

QGNBTYAQAPLTMX-UHFFFAOYSA-L

Descripción general

Dobesilate calcium belongs to the family of fibroblast growth factor (FGF) inhibitors.

Aplicación

Dobesilate calcium has been used to study its interference in different in vitro assay systems for the determination of creatinine, uric acid, cholesterol, and triglycerides.

Acciones bioquímicas o fisiológicas

Dobesilate Calcium is a vasoprotectant used as a treatment for chronic venous disease, diabetic retinopathy and other microvascular disorders. Its mechanism of action is not fully understood. It appears that dobesilate calcium increases endothelial nitric oxide levels by enhancing the activity of nitric oxide synthase and decreasing capillary hyperpermeability. Also in diabetic retinopathy dobesilate calcium prevents the blood-retinal barrier breakdown induced by diabetes by restoration of the tight junction protein, and decreasing the leukocyte adhesion to retinal vessels.
Dobesilate calcium inhibits the action of fibroblast growth factor by binding to its heparin-binding domain. It is also useful in treating rosacea and psoriasis, characterized with uncontrolled angiogenesis and vascular endothelial growth factor overexpression.

Características y beneficios

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H315,H319,H335

Clasificaciones de peligro

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
102M4707V

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Jaimi A Gray et al.
BMC evolutionary biology, 19(1), 7-7 (2019-01-10)
Morphological diversity among closely related animals can be the result of differing growth patterns. The Australian radiation of agamid lizards (Amphibolurinae) exhibits great ecological and morphological diversity, which they have achieved on a continent-wide scale, in a relatively short period
Xiuzhi Guo et al.
Clinica chimica acta; international journal of clinical chemistry, 483, 1-5 (2018-04-14)
We reported that calcium dobesilate, a vasoprotective agent mainly used for diabetic retinopathy (DR), negatively interferes with glycated albumin (GA) assays involving enzymatic methods. A calcium dobesilate standard was added to 3serum pools in vitro to prepare concentration-response series according
Negative interferences by calcium dobesilate in the detection of five serum analytes involving Trinder reaction-based assays.
Guo X, et al.
PLoS ONE, 13(2), e0192440-e0192440 (2018)
Xiuzhi Guo et al.
Medicine, 94(23), e905-e905 (2015-06-11)
The vasoprotective drug calcium dobesilate is known to interfere with creatinine (Cr) quantifications in sarcosine oxidase enzymatic (SOE) assays. The aim of this study was to investigate this interference in 8 different commercially available assays and to determine its clinical
XinYuan Zhang et al.
Science China. Life sciences, 58(1), 101-107 (2014-12-22)
Many randomized clinical controlled trials have confirmed the efficacy and safety of calcium dobesilate in treating diabetic retinopathy (DR). This systematic review critically evaluated the evidence that links calcium dobesilate to DR. In this fixed-effects meta-analysis, a total of 221
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