F4381

Furosemide

≥98% (HPLC), powder, NKCC symporter inhibitor

• Sinónimos: 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid, 5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid
• Fórmula empírica (notación de Hill): C₁₂H₁₁ClN₂O₅S
• Número de CAS: 54-31-9
• Peso molecular: 330.74
• Número CE: 200-203-6
• Número MDL: MFCD00010549
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24277714
• NACRES: NA.77

Propiedades

• Nombre del producto: Furosemide,
• origen biológico: synthetic (organic)
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• mp: 220 °C (dec.) (lit.)
• solubilidad: acetone: 50 mg/mL, clear to slightly hazy, colorless to yellow
• emisor: Sanofi Aventis
• temp. de almacenamiento: room temp
• cadena SMILES: NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl
• InChI: 1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)
• Clave InChI: ZZUFCTLCJUWOSV-UHFFFAOYSA-N
• Información sobre el gen: human ... ALB(213) , CYP1A2(1544) , SLC12A1(6557)

Descripción

Descripción general

Furosemide is a an ototoxic high-ceiling diuretic.

Aplicación

Furosemide has been used:

• to investigate the influence of timing of dexamethasone administration on auditory hair cell survival in mice
• to study its effect on intracranial pressure (ICP) after subcutaneous administration in rats
• as a stimulant for renin release and subsequent increase in plasma angiotensin II (ANG II)

Acciones bioquímicas o fisiológicas

"High ceiling" diuretic that strongly affects renal tubular action by increasing renal blood flow; antihypertensive.

Furosemide can block the Na⁺/K⁺/2Cl^- co-transporter in the ascending thick loop of Henle. It can enhance the synthesis of intrarenal prostaglandin. It enhances its ototoxicity in animals when used along with kanamycin. Furosemide is linked with thiamine insufficiency in individuals with heart failure.

Inhibits ion co-transport in the kidney.

Características y beneficios

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS08,GHS07
• Palabra de señalización: Danger
• Frases de peligro: H302,H360FD
• Consejos de prudencia: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Clasificaciones de peligro: Acute Tox. 4 Oral - Repr. 1B
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges