SML0474

(S)-Duloxetine hydrochloride

≥98% (HPLC)

• Sinónimos: (γS)-N-Methyl-γ-(1-naphthalenyloxy)-2-thiophenepropanamine hydrochloride, (+)-(S)-N-Methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine hydrochloride, (+)-N-Methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine hydrochloride, LY-248686 hydrochloride
• Fórmula empírica (notación de Hill): C₁₈H₁₉NOS · HCl
• Número de CAS: 136434-34-9
• Peso molecular: 333.88
• Número MDL: MFCD06407958
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825429
• NACRES: NA.77

Propiedades

• Análisis: ≥98% (HPLC)
• formulario: powder
• actividad óptica: [α]/D +116 to +125°, c = 1 in methanol
• condiciones de almacenamiento: desiccated
• color: white to beige
• solubilidad: H₂O: 5 mg/mL (clear solution, warmed)
• temp. de almacenamiento: room temp
• cadena SMILES: Cl.CNCC[C@H](Oc1cccc2ccccc12)c3cccs3
• InChI: 1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/t17-;/m0./s1
• Clave InChI: BFFSMCNJSOPUAY-LMOVPXPDSA-N
• Información sobre el gen: human ... SLC6A2(6530) , SLC6A4(6532)

Descripción

Descripción general

(S)-Duloxetine hydrochloride belongs to the class of serotonin and norepinephrine reuptake inhibitors. Duloxetine is a thiophene derivative. It is used to treat stress urinary incontinence, psychiatric and metabolic disorders. It is also used for treating diabetic peripheral neuropathic pain, fibromyalgia, chronic musculoskeletal and low back pain (LBP). Duloxetine is a cytochrome P450 2D6 (CYP2D6) inhibitor.

Aplicación

(S)-Duloxetine hydrochloride has been used as an antidepressant in rats exposed to chronic mild stress (CMS).

Acciones bioquímicas o fisiológicas

Duloxetine hydrochloride is a dual serotonin/norepinephrine reuptake inhibitor (SNRI), widely used clinically as an antidepressant and anxiolytic.

Características y beneficios

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Precaución

air sensitive

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Consejos de prudencia: P264 - P270 - P301 + P312 - P501
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable