SML0181

S 17092

≥98% (HPLC)

• Sinónimos: (2S,3aS,7aS)-1-(((R,R)-2-Phenylcyclopropyl)carbonyl)-2-((thiazolidin-3-yl)carbonyl)octahydro-1H-indole, [(2S,3aS,7aS)-Octahydro-1-[[(1R,2R)-2-phenylcyclopropyl]carbonyl]-1H-indol-2-yl]-3-thiazolidinyl--methanone
• Fórmula empírica (notación de Hill): C₂₂H₂₈N₂O₂S
• Número de CAS: 176797-26-5
• Peso molecular: 384.53
• Número MDL: MFCD00948255
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825210
• NACRES: NA.77

Propiedades

• Análisis: ≥98% (HPLC)
• formulario: powder
• actividad óptica: [α]/D -140 to -170° in dichloromethane
• color: white to tan
• solubilidad: DMSO: ≥10 mg/mL
• temp. de almacenamiento: 2-8°C
• cadena SMILES: O=C([C@@H]1C[C@@H]2CCCC[C@@H]2N1C(=O)[C@@H]3C[C@H]3c4ccccc4)N5CCSC5
• InChI: 1S/C22H28N2O2S/c25-21(18-13-17(18)15-6-2-1-3-7-15)24-19-9-5-4-8-16(19)12-20(24)22(26)23-10-11-27-14-23/h1-3,6-7,16-20H,4-5,8-14H2/t16-,17-,18+,19-,20-/m0/s1
• Clave InChI: NXSXRIHXEQSYEZ-KNJMJIDISA-N

Descripción

Aplicación

S 17092 may be used in prolyl endopeptidase-mediated cell signaling studies.

Acciones bioquímicas o fisiológicas

S-17092 is a potent, selective inhibitor of Prolyl oligopeptidase (POP), also known as prolyl endopeptidase (PEP or PE). Ki=1.5 nM. Nootropic.

S-17092 inhibition of POP prevents breakdown and thus increases the activity of a number of neuropeptides, which is likely the basis for its nootropic activity. S 17092 has been shown to improve cognition. It improved cognitive task performance in chronic low dose MPTP-treated monkeys. S-17092 was recently used to inhibit the formation of AcSDKP from its precursor 43-mer thymosin ?4 (T?4). Ac-SDKP is involved in hemopoietic stem cell differentiation, is pro-angiogenic and antifibrogenic.

Características y beneficios

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Consejos de prudencia: P264 - P270 - P301 + P312 - P501
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable