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SML0038

Sigma-Aldrich

Fluvastatin sodium hydrate

≥98% (HPLC)

Sinónimos:

(±)-(3R*,5S*,6E)-7-[3-(4-Fluorophenyl)-1-(1-methyethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt hydrate

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About This Item

Fórmula empírica (notación de Hill):
C24H25FNO4 · Na · xH2O
Número de CAS:
93957-55-2
Peso molecular:
433.45 (anhydrous basis)
Número MDL:
MFCD20488050
Código UNSPSC:
12352204
ID de la sustancia en PubChem:
329825108
NACRES:
NA.77

Análisis

≥98% (HPLC)

formulario

powder

condiciones de almacenamiento

desiccated

color

white to tan

solubilidad

H2O: ≥9 mg/mL

emisor

Novartis

temp. de almacenamiento

2-8°C

cadena SMILES

O.[Na+].CC(C)n1c(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)c(-c2ccc(F)cc2)c3ccccc13

InChI

1S/C24H26FNO4.Na.H2O/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);;1H2/q;+1;/p-1/b12-11+;;/t18-,19-;;/m1../s1

Clave InChI

KKEMYLLTGGQWCE-PMRANXHDSA-M

Aplicación

Fluvastatin sodium hydrate has been used:
  • to examine its effect on β -glucan-induced training on immunity
  • to investigate the effect of statins on the number of uncoupling protein 1 (UCP1)+ cells
  • to determine its effect on insulin degrading enzyme (IDE) secretion from astrocytes
  • to treat and study its effect on human umbilical vein endothelial cells (HUVECs) in vitro

Fluvastatin sodium hydrate has been used:
  • to test its anti-hepatitis C virus (HCV) activity
  • as a cholesterol inhibitor
  • to study its effects on β-glucan-induced monocyte immune training

Acciones bioquímicas o fisiológicas

Fluvastatin has antifungal activity.
Fluvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.

Características y beneficios

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Kazuho Sakamoto et al.
The Journal of pharmacology and experimental therapeutics, 338(1), 62-69 (2011-04-07)
HMG-CoA reductase inhibitor statins are used for the treatment of hypercholesterolemia. However, statins have adverse effects on skeletal muscles with unknown mechanism. We have reported previously that fluvastatin induced vacuolation and cell death in rat skeletal myofibers by depleting geranylgeranylpyrophosphate
Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway
Son SM, et al.
Mol. Neurodegener., 10(1), 56-56 (2015)
Inhibition of mevalonate pathway prevents adipocyte browning in mice and men by affecting protein prenylation
Balaz M, et al.
Cell Metabolism, 29(4), 901-916 (2019)
Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-beta in iPSC-Derived Alzheimer?s Disease Neurons
van der Kant R, et al.
Cell Stem Cell, 24(3), 363-375 (2019)
Erica Españo et al.
Scientific reports, 9(1), 11461-11461 (2019-08-09)
Zika virus (ZIKV) is a mosquito-borne member of the Flaviviridae family. ZIKV infection has been associated with neurological complications such as microcephaly in newborns and Guillain-Barré syndrome in adults; thus, therapeutic agents are urgently needed. Statins are clinically approved for
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Antilipemic Agents

Randomized controlled clinical studies have suggested 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are effective in both primary and secondary prevention of cardiovascular disease (CVD) events.

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