SMB00378

Diallyl disulfide

≥98% (HPLC)

• Sinónimos: Allyl disulfide, Diallyl disulfide
• Fórmula lineal: CH₂=CHCH₂SSCH₂CH=CH₂
• Número de CAS: 2179-57-9
• Peso molecular: 146.27
• Beilstein: 1699241
• Número CE: 218-548-6
• Número MDL: MFCD00008656
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329824979
• NACRES: NA.25

Propiedades

• origen biológico: Allium sativum L.
• Nivel de calidad: 200
• densidad de vapor: >5 (vs air)
• presión de vapor: 1 mmHg ( 20 °C)
• Análisis: ≥98% (HPLC)
• formulario: oil
• color: colorless to yellow
• índice de refracción: n20/D 1.541 (lit.)
• bp: 180-195 °C (lit.)
• densidad: 1.008 g/mL at 25 °C (lit.)
• aplicaciones: metabolomics; vitamins, nutraceuticals, and natural products
• temp. de almacenamiento: −20°C
• cadena SMILES: C=CCSSCC=C
• InChI: 1S/C6H10S2/c1-3-5-7-8-6-4-2/h3-4H,1-2,5-6H2
• Clave InChI: PFRGXCVKLLPLIP-UHFFFAOYSA-N

Descripción

Descripción general

Diallyl disulfide (DADS) is an oil-soluble volatile organosulfur compound that can be naturally found in Allium sativum (garlic). It has a simple chemical structure with two sulfur atoms attached with two allyl groups. This constitute of garlic contributes to its pungent aroma.

Aplicación

Diallyl disulfide has been used:

• to study its effects in apoptosis induction and cell viability on different glioma cell lines
• as a treatment and positive control to assess the anti-inflammatory regulation of nuclear factor erythroid-2 related factor-2 (Nrf2) in breast cancer cells
• as a potential substrate compound to detect hydrogen sulfide (H₂S) production via lead acetate/lead sulfide method

Acciones bioquímicas o fisiológicas

Diallyl disulfide is a potent anticancer agent. It can reduce carcinogen-induced cancers and shows anti-proliferative effects in both in vivo and in vitro models. DADS enhances the anti-obesity and anti-inflammatory effects of green tea in high-fat/high-sucrose (HF/HS) diet-fed mice. It also displays antioxidant, anti-microbial, cardiovascular protective, and neuroprotective activities. DADS elicits anti-mitotic and anti-neoplastic effects and arrests mitosis in colon neoplastic lesions in vivo and colon tumor cell growth in vitro experiments.

Organosulfur compound that is naturally found in garlic. Contributes to the pungent odor of crushed garlic. Anticancer agent and may provide protection against cardiovascular disease.

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H301,H315,H319,H335
• Consejos de prudencia: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): 143.6 °F - closed cup
• Punto de inflamabilidad (°C): 62 °C - closed cup