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Merck
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Documentos clave

SCP0200

Sigma-Aldrich

Neuromedin N

Sinónimos:

NMN-125, NN, NT/N, NmN

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About This Item

Fórmula empírica (notación de Hill):
C38H63N7O8
Peso molecular:
745.95
Código UNSPSC:
12352200
NACRES:
NA.32

Ensayo

≥95% (HPLC)

Formulario

lyophilized

composición

Peptide Content, ≥65%

condiciones de almacenamiento

protect from light

Nº de acceso UniProt

P30990

temp. de almacenamiento

−20°C

Información sobre el gen

human ... NTS(4922)

Amino Acid Sequence

Lys-Ile-Pro-Tyr-Ile-Leu

Acciones bioquímicas o fisiológicas

Neuromedin N is a hexapeptide that is related to neurotensin. Its precursor, proneuromedin N, is expressed in the adrenals, brain, gut and also in several cancers. In myoelectric activity, it has been reported to act in a similar manner as neurotensin, at a lesser degree of potency. Neuromedin N has been shown to increase the chemotaxis capacity of mouse lymphocytes and to modulate function of the hypothalamo-pituitary-adrenocortical axis in rats. Neuromedin N has been proposed to exert its actions via increase in intracellular Ca2+ concentration, although this is uncertain.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
CL0446

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I Schultz et al.
Regulatory peptides, 35(3), 197-205 (1991-09-03)
The effects of neuromedin-N on migrating myoelectric complexes in the small intestine of rats were studied. As neuromedin-N and neurotensin are structurally related peptides a comparison with neurotensin was made. Myoelectric activity was recorded by means of three bipolar electrodes
Investigation of proNT/NMN secretion from small cell lung carcinoma cells using a mouse xenograft model.
Wakabayashi-Nakao K
Oncology Reports, 28(4), 1181-1186 (2012)
M De la Fuente et al.
Journal of neuroimmunology, 42(1), 97-104 (1993-01-01)
The neuropeptides neurotensin and neuromedin N (from 10(-12) M to 10(-9) M) have been shown in this study to stimulate significantly in vitro several steps of the phagocytic process: adherence to substrate, chemotaxis, ingestion of inert particles (latex beads) and
E B Binder et al.
Pharmacological reviews, 53(4), 453-486 (2001-12-06)
Interactions between the classical monoamine neurotransmitter dopamine (DA) and the peptide neurotransmitter neurotensin (NT) in the central nervous system (CNS) have now been investigated for over two decades. Interest in this topic has been sustained, primarily because of the potential
J J Garrido et al.
Regulatory peptides, 41(1), 27-37 (1992-09-03)
The action of neurotensin and related peptides has not been yet studied on lymphocytes, although there are studies indicating the stimulative action of neurotensin, a peptide first isolated from bovine hypothalamus, on different functions of phagocytic immune cells. The present
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