SCP0054
Endothelin Big 1-38 human
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About This Item
Fórmula empírica (notación de Hill):
C189H282N48O56S5
Peso molecular:
4282.87
Código UNSPSC:
12352200
NACRES:
NA.32
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![[Ala1,3,11,15]-Endothelin 1](/deepweb/assets/sigmaaldrich/product/structures/257/425/5e642291-a643-4523-a7f1-65d3e6e51aa8/640/5e642291-a643-4523-a7f1-65d3e6e51aa8.png)
Ensayo
≥95% (HPLC)
Formulario
lyophilized
composición
Peptide Content, ≥75%
condiciones de almacenamiento
protect from light
temp. de almacenamiento
−20°C
Amino Acid Sequence
Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser
Aplicación
Endothelin Big (1-38) is the precursor of Endothelin 1. [D-Val22]-Endothelin-1 Big fragment (16-38) is used to inhibit endothelin-converting enzyme activity.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
G C Hanson et al.
Regulatory peptides, 68(1), 63-69 (1997-01-15)
The hydrolysis of human big endothelin 1-38 (bigET-1) was investigated in the membrane fractions from three human lung specimens. The hydrolysis products were identified by HPLC or by amino acid analysis, peptide sequencing and mass spectrometry, and the contractile effects
Marie-Hélène Fecteau et al.
Hypertension (Dallas, Tex. : 1979), 46(1), 87-92 (2005-06-16)
The precursor of endothelin-1, big endothelin-1, can be hydrolyzed by chymase to generate endothelin-1 (1-31) in vitro. In the present study, we explored the processes involved in the production of endothelin-1 (1-31) as well as its pharmacodynamic characteristics in the
Michael Zimmermann et al.
Neurosurgical review, 26(2), 125-132 (2003-09-10)
The aim of this study was to investigate whether the blocking of endothelin-converting enzyme (ECE) activity offers a new approach to inhibiting the development of cerebral vasospasm after subarachnoid hemorrhage (SAH) by preventing transformation of big endothelin-1 (big ET-1) to
Vasileios Kalles et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 33(4), 1231-1236 (2012-03-15)
Deregulation of the endothelin system, comprised of endothelin-1 (ET-1), its isoforms (ET-2 and ET-3) and their receptors (ET(A)R and ET(B)R), is under investigation in various types of human cancer. ET-1 has been suggested to participate in breast cancer development and
A Morita et al.
FEBS letters, 353(1), 84-88 (1994-10-10)
Endothelin converting enzyme (ECE) is essential for generation of the biological effects of endothelin-1 (ET-1) from a precursor, big endothelin-1 (Big ET-1). We synthesized four analogs of human Big ET-1[16-38], substituted with single D-amino acids at P1, P2, P1' and
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