SBR00017
Puromycin aminonucleoside Ready Made Solution
10 mg/mL in water
Sinónimos:
3′-Amino-3′-deoxy-N6,N6-dimethyladenosine
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About This Item
Fórmula empírica (notación de Hill):
C12H18N6O3
Número de CAS:
Peso molecular:
294.31
Código UNSPSC:
51281912
NACRES:
NA.85
Productos recomendados
Ensayo
≥98%
Nivel de calidad
Formulario
liquid
concentración
10 mg/mL in water
espectro de actividad antibiótica
Gram-positive bacteria
neoplastics
parasites
Modo de acción
protein synthesis | interferes
temp. de almacenamiento
2-8°C
cadena SMILES
N[C@H]1[C@@H](O)[C@H](N(C=N2)C3=C2C(N(C)C)=NC=N3)O[C@@H]1CO
InChI
1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3
Clave InChI
RYSMHWILUNYBFW-UHFFFAOYSA-N
Acciones bioquímicas o fisiológicas
Puromycin aminonucleoside is an aminonucleoside derivative of the known antibiotic puromycin. Puromycin aminonucleoside has been used in nephrology research, studying focal and segmental glomerulosclerosis, and in the induction of nephrosis in rats. Rats with puromycin aminonucleoside-induced nephrotic syndrome were used to study the excretion of sodium and NOx metabolites.
Puromycin aminonucleoside has also been used to probe endothelial glycosaminoglycan synthesis in cultured glomerular endothelial cells and their relation to cell permeability. A puromycin aminonucleoside nephrosis model of rat glomerular disease was also used to study the role of the neuron-specific ubiquitin C-terminal hydrolase protein gene product 9.5 (PGP 9.5).
Puromycin aminonucleoside has also been used to probe endothelial glycosaminoglycan synthesis in cultured glomerular endothelial cells and their relation to cell permeability. A puromycin aminonucleoside nephrosis model of rat glomerular disease was also used to study the role of the neuron-specific ubiquitin C-terminal hydrolase protein gene product 9.5 (PGP 9.5).
Nota de preparación
Puromycin aminonucleoside solution is provided at 10 mg/mL in water and could be further diluted in aqueous buffers to a working concentration of 10 μg/mL (1:1000).
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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