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SAE0066

Sigma-Aldrich

Adenylyl Cyclase Toxin from Bordetella pertussis

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About This Item

Código UNSPSC:
12352200
NACRES:
NA.26

origen biológico

Bordetella pertussis Tohama I

Nivel de calidad

Análisis

≥70%

formulario

liquid

actividad específica

≥ 50  units/mg protein

técnicas

cell culture | mammalian: suitable

idoneidad

suitable for molecular biology

aplicaciones

detection

temp. de almacenamiento

−20°C

Información sobre el gen

Bordetella pertussis Tohama I ... CyaA(69600712)

Descripción general

Research area: IMMUNO AND CKS

Adenylate Cyclase Toxin (ACT or CyaA) is a member of the extensive family of toxins known as Repeat in Toxin (RTX), which are produced by Gram-negative organisms. ACT is encoded by the cyaA gene and secreted extracellularly in the form of a soluble protein. It exhibits both adenylate cyclase enzymatic activity and hemolytic activity. The synthesis, maturation, and secretion of ACT are regulated by the CyaCABD operon. Moreover, its specific cellular receptor, CD11b/CD18 integrin (αMβ2, Mac-1, or CR3), is expressed on myeloid phagocytes.

Aplicación

Adenylyl Cyclase Toxin from Bordetella pertussis has been used as Gα(i/o) inhibitor to study the involvement of the sphingosine 1-phosphate receptor 2/Gα(12/13)/MAPK signaling pathway in the priming and activation of NLRP3 inflammasome during cholestatic liver injury.

Acciones bioquímicas o fisiológicas

Adenylate Cyclase Toxin (CyaA) is responsible for inhibiting the phagocytic activities of neutrophils and macrophages by impairing oxidative response and chemotaxis, ultimately leading to cell apoptosis or necrosis. Additionally, ACT can upregulate the expression of MHC class II and costimulatory molecules on dendritic cells, thereby reducing proinflammatory cytokine production.

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Lei Hou et al.
Journal of molecular medicine (Berlin, Germany), 99(2), 273-288 (2021-01-04)
NLRP3 inflammasome-driven inflammation represents a key trigger for hepatic fibrogenesis during cholestatic liver injury. However, whether sphingosine 1-phosphate (S1P) plays a role in NLRP3 inflammasome priming and activation remains unknown. Here, we found that the expression of NLRP3 in macrophages
Yao Wei et al.
Nature communications, 11(1), 941-941 (2020-02-20)
Oxidative stress is a major pathogenic mechanism in Parkinson's disease (PD). As an important cellular antioxidant, glutathione (GSH) balances the production and incorporation of free radicals to protect neurons from oxidative damage. GSH level is decreased in the brains of

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