SAB5700387

Anti-Phospho-p38 MAPK-T180/Y182 antibody produced in rabbit

• Sinónimos: CSBP, CSBP1, CSBP2, CSPB1, EXIP, MAPK14, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38 MAPK, p38ALPHA
• Código UNSPSC: 12352203
• NACRES: NA.43

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• mol peso: 29; 34; 35; 41
• reactividad de especies: mouse, human, rat
• concentración: 5.56 mg/ml
• técnicas: immunofluorescence: 1:50-1:200; western blot: 1:500-1:2000
• Nº de acceso UniProt: Q16539
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: phosphorylation (pThr180/pTyr182)
• Información sobre el gen: human ... MAPK14(1432)

Descripción

Descripción general

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Inmunógeno

A synthetic phosphorylated peptide around T180 & Y182 of human p38 MAPK (NP_620581.1).

Forma física

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Almacenamiento y estabilidad

Store at -20℃. Avoid freeze / thaw cycles.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable