SAB5700022

Anti-ROCK1 antibody produced in rabbit

• Sinónimos: P160ROCK, ROCK-I, ROCK1
• Código UNSPSC: 12352203
• NACRES: NA.41
• clon: polyclonal
• application: IHC; IP; WB
• reactividad de especies: rat, human, mouse
• técnicas: immunohistochemistry: 1:50-1:100; immunoprecipitation (IP): 1:50-1:100; western blot: 1:500-1:2000

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• mol peso: 158
• reactividad de especies: rat, human, mouse
• concentración: 1.67 mg/ml
• técnicas: immunohistochemistry: 1:50-1:100; immunoprecipitation (IP): 1:50-1:100; western blot: 1:500-1:2000
• Nº de acceso UniProt: Q13464
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... ROCK1(6093)

Descripción

Descripción general

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18.

Inmunógeno

Recombinant fusion protein containing a sequence corresponding to amino acids 400-660 of human ROCK1 (NP_005397.1).

Forma física

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Almacenamiento y estabilidad

Store at -20℃. Avoid freeze / thaw cycles.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable