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SAB5300353

Monoclonal Anti-CASP8 antibody produced in mouse

Name: Monoclonal Anti-CASP8 antibody produced in mouse
Brand: SIGMA

clone 1H11, ascites fluid

Sinónimos:

ALPS2B, CAP4, FLICE, MACH, MCH5

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About This Item

Código UNSPSC:

12352203

NACRES:

NA.41

origen biológico

mouse

Nivel de calidad

100

conjugado

unconjugated

forma del anticuerpo

ascites fluid

tipo de anticuerpo

primary antibodies

clon

1H11, monoclonal

mol peso

26 kDa

reactividad de especies

human, mouse, rat, monkey

técnicas

direct ELISA: 1:10,000
flow cytometry: 1:200-1:400
immunohistochemistry: 1:200-1:1,000
western blot: 1:500-1:2,000

isotipo

IgG1

Nº de acceso NCBI

NM_001080124

Nº de acceso UniProt

Q14790

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

Información sobre el gen

human ... CASP8(841)

Inmunógeno

Purified recombinant fragment of human CASP8 expressed in E.coli.
Mouse monoclonal antibody raised against CASP8

Forma física

Ascitic fluid containing 0.03% sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

PM1108292

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Chemosensitization of rhabdomyosarcoma cells by the histone deacetylase inhibitor SAHA.

Ulrike Heinicke et al.

Cancer letters, 351(1), 50-58 (2014-05-13)

Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in childhood with a dismal prognosis, highlighting the need for novel treatment strategies. Here, we identify a novel synthetic lethal interaction between the histone deacetylase inhibitor (HDACI) SAHA and anticancer drugs in

Ultrasound-targeted microbubble destruction combined with dual targeting of HSP72 and HSC70 inhibits HSP90 function and induces extensive tumor-speciﬁc apoptosis.

Hanghui Wang et al.

International journal of oncology, 45(1), 157-164 (2014-04-17)

The specific and efficient delivery of small interfering RNA (siRNA) into cancer cells in vivo remains a major obstacle. In this study, we investigated whether ultrasound-targeted microbubble destruction (UTMD) combined with dual targeting of HSP72 and HSC70 in prostate cancer cell

Mitochondria autophagy is induced after hypoxic/ischemic stress in a Drp1 dependent manner: the role of inhibition of Drp1 in ischemic brain damage.

Wei Zuo et al.

Neuropharmacology, 86, 103-115 (2014-07-16)

Mitochondria dysfunction is implicated in diverse conditions, including metabolic and neurodegenerative disorders. Mitochondrial dynamics has attracted increasing attention as to its relationship with mitochondria autophagy, also known as mitophagy, which is critical for degradation of dysfunctional mitochondria maintaining mitochondrial homeostasis.

Caspase-8 mutations in head and neck cancer confer resistance to death receptor-mediated apoptosis and enhance migration, invasion, and tumor growth.

Changyou Li et al.

Molecular oncology, 8(7), 1220-1230 (2014-05-13)

Little is known regarding molecular markers in head and neck squamous cell carcinoma (HNSCC) that predict responsiveness to different therapeutic regimens or predict HNSCC progression. Mutations in procaspase-8 occur in 9% of HNSCC primary tumors, but the functional consequences of

Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening.

Sireesha V Garimella et al.

Breast cancer research : BCR, 16(2), R41-R41 (2014-04-22)

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) binds to its receptors, TRAIL-receptor 1 (TRAIL-R1) and TRAIL-receptor 2 (TRAIL-R2), leading to apoptosis by activation of caspase-8 and the downstream executioner caspases, caspase-3 and caspase-7 (caspase-3/7). Triple-negative breast cancer (TNBC) cell lines with

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