SAB4504670

Anti-phospho-FRS2 (pTyr⁴³⁶) antibody produced in rabbit

affinity isolated antibody

• Código UNSPSC: 12352203
• NACRES: NA.41
• conjugado: unconjugated
• application: ELISA; IHC; WB
• clon: polyclonal
• reactividad de especies: rat, mouse, human
• citations: 3
• técnicas: ELISA: 1:10000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• mol peso: antigen 57 kDa
• reactividad de especies: rat, mouse, human
• concentración: ~1 mg/mL
• técnicas: ELISA: 1:10000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• Nº de acceso NCBI: Q8WU20
• Nº de acceso UniProt: Q8WU20
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: phosphorylation (pTyr436)
• Información sobre el gen: human ... FRS2(10818)

Descripción

Descripción general

Fibroblast growth factor (FGF) receptor substrate 2 (FRS2) is an FGF receptor (FGFR)-associated protein. It is a membrane-bound adaptor protein, that is located on human chromosome 12q15.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human FRS2 around the phosphorylation site of Tyr436.

Immunogen Range: 402-451

Acciones bioquímicas o fisiológicas

Fibroblast growth factor (FGF) receptor substrate 2 (FRS2) is essential for activation of downstream signaling molecules that are involved in the MAP (‎mitogen-activated protein kinase) and AKT (protein kinase B) kinase pathways. This protein plays an important role in epidermal growth factor (EGF) signaling. It also plays a major role in cell transformation and resistance to therapy. FRS2 helps to link FGF, nerve growth factor (NGF) and glial cell-derived neurotrophic factor (GDNF) receptors with the Ras/mitogen-activated protein (MAP) kinase signaling cascade.

Características y beneficios

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Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable