SAB4503836
Anti-phospho-STAT2 (pTyr690) antibody produced in rabbit
affinity isolated antibody
Sinónimos:
Anti-IMD44, Anti-ISGF-3, Anti-P113, Anti-PTORCH3, Anti-STAT113
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Productos recomendados
origen biológico
rabbit
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
buffered aqueous solution
mol peso
antigen 97 kDa
reactividad de especies
human, mouse, rat
concentración
~1 mg/mL
técnicas
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
phosphorylation (pTyr690)
Información sobre el gen
human ... STAT2(6773)
Descripción general
STAT2 (signal transducer and activator of transcription 2) is mapped to human chromosome 12.
Signal transducer and activator of transcription 2 (STAT2) belongs to the STAT family. The gene is located on human chromosome 12q13.3. STAT2 consists of 24 exons and has a molecular weight of 113 kDa. It consists of N-terminal domain (N), coiled-coil domain (CC), DNA-binding domain (DBD), linker domain (L), Src homology 2 domain (SH2), tyrosine phosphorylation site (Y) and transcriptional activation domain (TAD).
Inmunógeno
The antiserum was produced against synthesized peptide derived from human STAT2 around the phosphorylation site of Tyr690.
Immunogen Range: 656-705
Immunogen Range: 656-705
Aplicación
Anti-phospho-STAT2 (pTyr690) antibody produced in rabbit has been used in western blotting, immunofluorescence staining and flow cytometric staining.
Anti-phospho-STAT2 (pTyr690) antibody produced in rabbit has been used:
- for western blotting
- for immunofluorescence staining
- for flow cytometric staining
Acciones bioquímicas o fisiológicas
STAT2 (signal transducer and activator of transcription 2) participates in immunity. It plays a major role in interferon signaling pathways.
Signal transducer and activator of transcription 2 (STAT2) is activated by interferon-1 (IFN-I) and IFN-III. It aids protein-protein interactions and is essential for binding IRF9. STAT2 is required for the nuclear export of STAT2-IFN regulatory factor 9 (IRF9) and IFN-stimulated gene factor 3 (ISGF3). It plays a vital role in interactions with STAT1.
Características y beneficios
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Forma física
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Certificados de análisis (COA)
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The unique role of STAT2 in constitutive and IFN-induced transcription and antiviral responses
Blaszczyk K, et al.
Cytokine & Growth Factor Reviews, 29, 71-81 (2016)
Kai-Che Wei et al.
Frontiers in cellular and infection microbiology, 8, 268-268 (2018-09-07)
During the epidemic of the dengue virus (DENV) infection in Taiwan in 2014 and 2015, we observed an abnormally high frequency of increased scalp hair shedding in infected individuals that could not be explained by telogen effluvium. In this study
Fei Xing et al.
PloS one, 11(12), e0168696-e0168696 (2016-12-20)
Non-self RNA is recognized by retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), inducing type I interferons (IFNs). Type I IFN promotes the expression of IFN-stimulated genes (ISGs), which requires the activation of signal transducer and activator of transcription-1 (STAT1). We previously
Stanleyson V Hato et al.
Oncotarget, 8(33), 54434-54443 (2017-09-15)
Platinum-based chemotherapeutics are amongst the most powerful anti-cancer drugs. Although their exact mechanism of action is not well understood, it is thought to be mediated through covalent DNA binding. We investigated the effect of platinum-based chemotherapeutics on signaling through signal
IL-7Ralpha glutamylation and activation of transcription factor Sall3 promote group 3 ILC development
Liu B, et al.
Nature Communications, 8(1), 231-231 (2017)
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