SAB4300672

Anti-phospho-Stat2 (pTyr⁶⁹⁰) antibody produced in rabbit

affinity isolated antibody

• Sinónimos: Anti-ISGF-3, Anti-MGC59816, Anti-P113, Anti-STAT113
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• mol peso: ~113 kDa
• reactividad de especies: human
• concentración: 1 mg/mL
• técnicas: western blot: 1:500-1:1000
• isotipo: IgG
• secuencia del inmunógeno: (R-K-Yp-L-K)
• Nº de acceso NCBI: NM_005419.3
• Nº de acceso UniProt: P52630
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: phosphorylation (pTyr690)
• Información sobre el gen: human ... Stat2(6773)

Descripción

Descripción general

The antibody detects endogenous level of Stat2 only when phosphorylated at Tyrosine 690.

Inmunógeno

Peptide sequence around phosphorylation site of tyrosine 690 (R-K-Yp-L-K), according to the protein NP_005410.1

Características y beneficios

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Descripción de destino

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) hasbeen shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.

Forma física

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable