SAB4502546

Anti-BAX antibody produced in rabbit

affinity isolated antibody

• Sinónimos: Apoptosis regulator BAX, BAX, BCL2L4, Bcl-2-like protein 4, Bcl2-L-4
• Código UNSPSC: 12352203

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• mol peso: antigen 21 kDa
• reactividad de especies: rat, human, mouse
• concentración: ~1 mg/mL
• técnicas: ELISA: 1:1000; immunofluorescence: 1:100-1:500; western blot: 1:500-1:1000
• Nº de acceso NCBI: Q07812
• Nº de acceso UniProt: Q07812
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... BAX(581)

Descripción

Descripción general

Anti-BAX antibody detects endogenous levels of total BAX protein.

The BAX (BCL2 (B-cell lymphoma 2) associated X, apoptosis regulator) gene is mapped to human chromosome 19q13.33. It codes for α-helical globular protein. The protein contains eight amphipathic helices around a hydrophobic helix. Bax is known to be mostly localized in the cytoplasm.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human Bax.

Immunogen Range: 133-182

Aplicación

Anti-BAX, C-Terminal antibody produced in rabbit has been used in western blotting analysis.

Acciones bioquímicas o fisiológicas

BAX (BCL2 (B-cell lymphoma 2) associated X, apoptosis regulator) is predominantly associated with cellular homeostasis, cell cycle and pathogenesis of cell death particularly in cancer cells. In response to an apoptotic stimulus, Bax brings about mitochondrial dysfunction and apoptosis. Oligomerization of bax promotes mitochondrial outer membrane permeabilization.

Características y beneficios

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Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): nwg