SAB4501323

Anti-GRM5 antibody produced in rabbit

affinity isolated antibody

• Sinónimos: GPRC1E, GRM5, MGLUR5, Metabotropic glutamate receptor 5, mGluR5
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• mol peso: antigen 132 kDa
• reactividad de especies: mouse, rat, human
• concentración: ~1 mg/mL
• técnicas: ELISA: 1:10000; immunofluorescence: 1:100-1:500; western blot: 1:500-1:1000
• Nº de acceso NCBI: P41594
• Nº de acceso UniProt: P41594
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... GRM5(2915)

Descripción

Descripción general

Glutamate metabotropic receptor 5 (GRM5)/metabotropic glutamate receptor subtype 5 (mGluR5) is a seven-transmembrane G-protein-coupled protein. It contains two binding sites and a structural connection to the N-methyl-D-aspartate receptor (NMDA) through a scaffold protein chain. GRM5 gene is located on human chromosome 11q14.2. Anti-GRM5 antibody detects endogenous levels of total GRM5 protein.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human GRM5.

Immunogen Range: 21-70

Acciones bioquímicas o fisiológicas

Glutamate metabotropic receptor 5 (GRM5) protein participates in glutamate signaling, supporting the action of natural stimuli, the excitability of N-methyl-D-aspartate receptor (NMDA) receptor, and abnormal synaptic plasticity in addiction. It is important for the pathophysiology and to treat eating disorders. It controls the developmental variation dependent on glutamate. It also plays a key role in adaptive synaptic plasticity, long-term potentiation, and learning. The pharmacological inhibitors of mGlu5 may have a therapeutic possibility in Bulimia nervosa (BN). Absence of mGluR5 plays a pathogenic role in autism spectrum disorder (ASD).

Características y beneficios

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Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable